Community Research and Development Information Service - CORDIS
Faculty of Physical Chemistry
Novel in vitro methods for evaluation and anticipation of ischemic potential of anticancer and other drugs; cutback of health hazard, animal testing and time/cost of drug development
Contact Person
BACIC, Goran (Professor)
Head of the Deparment of Nuclear and Radiochemistry
Faculty of Physical Chemistry
http://www.ffh.bg.ac.yu/
Contact
Telephone: +381-11-630796
Fax: +381-11-187133
Collaboration
Company Expertise
Novel in vitro methods for evaluation and anticipation of ischemic potential of anticancer and other drugs; cutback of health hazard, animal testing and time/cost of drug developmentTitle: Novel in vitro methods for evaluation and anticipation of ischemic potential of anticancer and other drugs; cutback of health hazard, animal testing and time/cost of drug development
Type Details: Our research group has determined that ischemia, as a frequent cause of chemotherapy related cardiotoxicity, is based on the effects of antineoplastic drugs on the metabolism of erythrocytes. Based on this, we developed in vitro methodological set, which is able to anticipate and evaluate ischemic potential of particular drug.
Applicating this in vitro test and other methods, we are in ability to participate in:
1. Comprehensive studies of mechanisms of cardiotoxic effects of antineoplastic drugs, already in use or in clinical trails.
2. Investigations of ischemic vs. antitumour potential of new drugs in preclinical trials.
3. Development of prophylaxis for prevention of cardiac toxicity.
Potential effects of the application of our in vitro set are:
- Reduction of the hazard of therapy-related cardiological complications.
- Reduction of the usage of experimental animals in preclinical trials of new antineoplastic and other drugs, by its partial substitution with this in vitro method;
- Cutback of the cost and duration of preclinical trials.
Human and Institutional Resources
Our research group is composed of 3 University Professors, 4 Ph.D.'s and 4 Ph.D. students, with an expertise and experimental experience in the fields of medicine (oncology), biophysics, and biochemistry.
We have an access to equipment (NMR and EPR spectrometers, electrophoresis, HPLC, SPM including AFM, etc), laboratory consumables and experimental samples (blood of healthy volunteers of various age and sex, blood of oncological patients of various age and types of cancer treated with different anticancer drugs, cancer cell-lines, experimental rodents and transplantable tumors). At the National Cancer Research Center, we have an access to monitoring clinical trails of antineoplastic drugs within the guideline of the ethical committee.
More information at: http://www.ffh.bg.ac.yu/fp7
Programme (Collaboration EU R&D): FP7-HEALTH
Expiry Date: 2008-02-08
Target Partner
Expertise:Medical and pharmacological institutions
MSEs developing new compounds for cancer treatment
National cancer research centers
Organisation Details
Name:Faculty of Physical Chemistry
Department:Deparment of Nuclear and Radiochemistry; Department of Biophysical Chemistry
Address:Faculty of Physical Chemistry
Studentski trg 12-16
Belgrade 1000 SERBIA
Type: Research; Education
Number of Employees: 50 - 249
Keywords: Cancer;Chemotherapy;Cardiotoxicity;Ischemia;Preclinical trials;Clinical trials
RCN: 74624
Quality Validation Date: 2007-03-13
Update Date: 2007-07-25