Objective Problem: Ageing is associated with alterations of gene activities modulating the inflammatory and immune response. Stroke is a common health problem in the European Community and the leading cause of severe long-term disability. Inflammatory reactions within the brain as well as a systemic immune response are assumed to influence the outcome after stroke.Hypothesis: The extent and the progression of the immune response after stroke is altered in elderly patients. The age-dependent inflammatory reaction is a major determinant of the outcome after stroke.Aims: The age-dependent inflammatory reaction in brain following stroke will be characterised by functional genomics and proteomics in the ARGES-project. Furthermore, systemic markers of the inflammator y response after stroke will be identified in circulating leukocytes, which will serve as clinical indicators for potential therapeutical interventions. In addition to the genome-wide approach, we will specifically analyse the functional impact of a pre-selected pathway, the sphingomyelin-ceramide-cycle, considered to be critically involved in stroke-induced destructive processes.Significance: The project will substantially contribute to our understanding of the age-dependence of the inflammatory react ion following stroke, which has as yet not been sufficiently investigated. We expect that ARGES will deliver indicators for therapeutical interventions whose application may considerable improve the outcome after stroke. We thus will make a significant contribution to basic scientific knowledge, therapy and diagnostics of stroke. Fields of science medical and health sciencesclinical medicinepneumologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicssocial sciencessociologydemographymortalitymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicineneurologystroke Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-1.2.5-4 - Post genomic approaches for tackling complex multifactorial diseases (except Cancer) (especially orientated towards involvement of SMEs) Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator KLINIKUM DER FRIEDRICH-SCHILLER-UNIVERSITAET JENA EU contribution No data Address Fuerstengraben 18 JENA Germany See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF EAST ANGLIA United Kingdom EU contribution No data Address University Plain, NR4 7TJ NORWICH See on map Links Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address 101 rue de Tolbiac PARIS See on map Total cost No data BIOFRONTERA BIOSCIENCE GMBH Germany EU contribution No data Address Hemmelrather Weg201 LEVERKUSEN See on map Links Website Opens in new window Total cost No data RUHR UNIVERSITY BOCHUM Germany EU contribution No data Address Universitätsstraße 150 BOCHUM See on map Links Website Opens in new window Total cost No data FRIEDRICH-SCHILLER-UNIVERSITAET JENA Germany EU contribution No data Address Fuerstengraben 1 JENA See on map Total cost No data MEDIZINISCHE UNIVERSITÄT WIEN Austria EU contribution No data Address Spitalgasse 23 WIEN See on map Links Website Opens in new window Total cost No data UNIVERSITÄT BAYREUTH Germany EU contribution No data Address Universitätsstraße 30 BAYREUTH See on map Total cost No data