| Using European and international populations to identify autism susceptibility loci |
Project Acronym: AUTISM MOLGEN
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Project Status:Completed |
| Coordinator |
| Organization Name: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD |
| Contact Person: |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD |
Name: Name: BAILEY, Anthony James (Professor)
Tel: +44-1865226517
Fax: +44-1865762358
Email: Contact |
University Offices, Wellington Square |
| UNITED KINGDOM |
Region: SOUTH EAST (UK)
BERKSHIRE, BUCKINGHAMSHIRE, OXFORDSHIRE
Oxfordshire |
| Project URL: http://www.well.ox.ac.uk/monaco/autism/molgen.shtml |
Organization Type: Education |
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| Description |
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Objective:
We aim to identify susceptibility alíeles for autism spectrum disorders. To achieve this aim the main research groups in Europe will pool data and laboratory resources and exploit the potential of European genetically ¡so ated populations. The Autism STREP group of clinical researchers and laboratory scientists will pool data from 425 previously ascertained multiplex families and perform a meta-analysis to identify the top 6 susceptibility regions for autism spectrum disorders The fine mapping data on chromosomes 6q and 7q will also be analysed for parent of origin effects. Over the course of the project the group, working closely with national voluntary organisations will assess and genotype approximately 300 new multiplex and over 700 new singleton families to increase power to narrow these regions of linkage. The top susceptibility regions will be tested in genetically isolated populations of Finnish and Friesland singleton trios to search for extended haplotypes that may further refine the critical regions. Subsequently brain expressed candidate genes in these narrowed six regions of linkage will be tested for mutations and association with autism. This will involve screening candidate gen-as for mutations in sharing multiplex families by DHPLC. Additionally single nucleotide polymorphisms (SNPs) fiom the public databases that tag the haplotypic diversity across these genes will be identified in the multiplex and singleton samples. New variants and haplotype tag SNP's will be screened for association in both multiplex and singleton families. The members of this group have previously identified a number of potential candidate genes that will be tested for mutations/association in the enlarged sample of multiplex families. These genes include Reelin, LAMB1, CGEF2, GluR6 and several neuroligin genes. The results of these studies will be published in peer reviewed journals and also communicated more broadly to the interested public.
Achievements:
General information:
| Project Details |
| Start Date: 2005-10-01 |
End Date: 2009-03-31 |
| Duration: 42 months |
Project Reference: |
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| Project Cost: 2.38 million euro |
Project Funding: 1.99 million euro |
| Programme Acronym: FP6-LIFESCIHEALTH |
Programme Type:6th FWP (Sixth Framework Programme) |
| Subprogramme Area: LSH-2003-2.1.3-7 Genetics and neurobiology of autism |
Subject Index: Biotechnology; Life Sciences; Medicine, Health
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| Other Participants |
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| Other Participants |
| Organization Name: CENTER FOR AUTISME |
| Contact Person: |
Other |
| Name: PEDERSEN, Lennart (Dr) |
LAURENTSVEJ 14 |
| Tel: +45-44982355 |
| Fax: +45-44982353
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DENMARK |
| E-mail: Contact |
Region: DANMARK
Danmark
København og Frederiksberg Kommuner |
| URL: http://www.centerforautisme.dk |
Organization Type: Other |
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| Other Participants |
| Organization Name: ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA - DIPARTIMENTO DI BIOLOGIA EVOLUZIONISTICA SPERIMENTALE |
| Contact Person: |
Education |
| Name: MAESTRINI, Elena (Professor) |
Via Zamboni 33 |
| Tel: +39-0512094178 |
| Fax: +39-0512094286
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ITALY |
| E-mail: Contact |
Region: EMILIA-ROMAGNA
Bologna |
| URL: http://www.unibo.it |
Organization Type: Education |
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| Other Participants |
| Organization Name: DEUTSCHES KREBSFORSCHUNGSZENTRUM |
| Contact Person: |
Research |
| Name: POUSTKA, Annemarie (Professor) |
Im Neuenheimer Feld 280 |
| Tel: +49-6221-424742 |
| Fax: +49-6221-423454
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GERMANY |
| E-mail: Contact |
Region: BADEN-WÜRTTEMBERG
KARLSRUHE
Heidelberg, Stadtkreis |
| URL: http://www.dkfz.de |
Organization Type: Research |
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| Other Participants |
| Organization Name: INSTITUT PASTEUR |
| Contact Person: |
Research |
| Name: BOURGERON, Thomas (Dr) |
25-28, rue du Docteur Roux |
| Tel: +33-140613216 |
| Fax: +33-145688639
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FRANCE |
| E-mail: Contact |
Region: ÎLE DE FRANCE
Ile de France
Paris |
| URL: http://www.pasteur.fr |
Organization Type: Research |
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| Other Participants |
| Organization Name: HELSINKI UNIVERSITY CENTRAL HOSPITAL |
| Contact Person: |
Other |
| Name: JÄRVELÄ, Irma (Dr) |
Stenbäckinkatu 9 |
| Tel: +358-9-47175905 |
100 HELSINKI |
| Fax: +358-9-47174001
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FINLAND |
| E-mail: Contact |
Region: MANNER-SUOMI
UUSIMAA |
| URL: http://www.hus.fi |
Organization Type: Other |
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| Other Participants |
| Organization Name: GOTEBORG UNIVERSITY |
| Contact Person: |
Education |
| Name: GILLBERG, Christopher (Professor) |
Kungsgatan 12 |
| Tel: +46-31172152 |
| Fax: +46-31172169
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SWEDEN |
| E-mail: Contact |
Region: SVERIGE
VÄSTSVERIGE
Göteborgs och Bohus län |
| Organization Type: Education |
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| Other Participants |
| Organization Name: STICHTING UNIVERSITAIRE EN ALGEMENE KINDER- EN JEUGDPSYCHIATRIE NOORD-NEDERLAND |
| Contact Person: |
Other |
| Name: MINDERAA, Rudolf (Professor) |
Hanzeplein 1, 9713 GZ Groningen |
| Tel: +31-503681175 |
660 GRONINGEN |
| Fax: +31-503681192
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NETHERLANDS |
| E-mail: Contact |
Region: NOORD-NEDERLAND
GRONINGEN
Overig Groningen |
| URL: http://www.accare.nl |
Organization Type: Other |
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| Other Participants |
| Organization Name: UNIVERSITY MEDICAL CENTER, UTRECHT |
| Contact Person: |
Education |
| Name: DE JONGE, Maretha (Dr) |
Heidelberglaan 100 |
| Tel: +31-302507042 |
85500 UTRECHT |
| Fax: +31-302505444
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NETHERLANDS |
| E-mail: Contact |
Region: NOORD-NEDERLAND
FRIESLAND
Zuidwest-Friesland |
| URL: http://www.umcutrecht.nl |
Organization Type: Education |
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| Other Participants |
| Organization Name: NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS |
| Contact Person: |
Education |
| Name: TSIANTIS, John (Professor) |
CHRISTOU LADA 6 |
| Tel: +30-2107798748 |
| Fax: +30-2107473811
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GREECE |
| E-mail: Contact |
Region: ATTIKI |
| URL: http://www.uoa.gr |
Organization Type: Education |
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| Other Participants |
| Organization Name: JOHANN WOLFGANG GOETHE-UNIVERSITÄTSKLINIKUM |
| Contact Person: |
Education |
| Name: POUSTKA, Fritz (Professor) |
Theodor-Stern-Kai 7 |
| Tel: +49-6963015408 |
| Fax: +49-6963015843
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GERMANY |
| E-mail: Contact |
| URL: http://www.kgu.de |
Organization Type: Education |
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| Other Participants |
| Organization Name: UNIVERSITÉ DE TOULOUSE LE MIRAIL |
| Contact Person: |
Education |
| Name: ROGE, Bernadette (Professor) |
5 Allée Antonio Machado |
| Tel: +33-561494334 |
| Fax: +33-534504657
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FRANCE |
| E-mail: Contact |
Region: SUD-OUEST
MIDI-PYRÉNÉES
Haute-Garonne |
| URL: http://www.univ-tlse2.fr/ |
Organization Type: Education |
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| Other Participants |
| Organization Name: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE |
| Contact Person: |
Research |
| Name: LEBOYER, Marion (Dr) |
101 rue de Tolbiac |
| Tel: +33-149813051 |
| Fax: +33-149813059
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FRANCE |
| E-mail: Contact |
Region: ÎLE DE FRANCE
Ile de France
Paris |
| URL: http://www.inserm.fr |
Organization Type: Research |
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| Other Participants |
| Organization Name: KINGS COLLEGE LONDON |
| Contact Person: |
Education |
| Name: BOLTON, Patrick Farrar (Professor) |
Strand |
| Tel: +44-02078485325 |
| Fax: +44-02078480866
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UNITED KINGDOM |
| E-mail: Contact |
Region: SOUTH EAST (UK)
GREATER LONDON |
| URL: http://www.kcl.ac.uk |
Organization Type: Education |
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| Other Participants |
| Organization Name: THE UNIVERSITY OF NEWCASTLE |
| Contact Person: |
Education |
| Name: LE COUTEUR, Ann Simone (Professor) |
6 Kensington Terrace |
| Tel: +44-1912225982 |
| Fax: +44-1912225062
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UNITED KINGDOM |
| E-mail: Contact |
Region: NORTH
NORTHUMBERLAND, TYNE AND WEAR
Tyne and Wear |
| URL: http://www.ncl.ac.uk |
Organization Type: Education |
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| Other Participants |
| Organization Name: STELLA MARIS CLINICAL RESEARCH INSTITUTE FOR CHILD & ADOLESCENT NEUROPSYCHIATRY |
| Contact Person: |
Research |
| Name: BATTAGLIA, Agatino (Professor) |
via dei Giacinti, 2 |
| Tel: +39-050886248 |
| Fax: +39-05032214
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ITALY |
| E-mail: Contact |
Region: CENTRO (I)
TOSCANA
Pisa |
| Organization Type: Research |
Record Control Number:
75703
Update Date: 2013-04-16 11:07:50.0
Quality Validation Date: 2013-03-26
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