Project description Virtual Physiological Human Show the project objective Hide the project objective Synergy will develop a simulation environment and a decision-support system aiming at enabling deployment of systems medicine. The three core elements are a knowledge base (KB), an inference engine (IE), and a graphical visualisation environment (GVE). The project focuses on patients with chronic obstructive pulmonary disease (COPD).The KB will include five well established physiological models addressing: 1) Central and peripheral O2 transport and utilization, 2) Pulmonary gas exchange, 3) Regional-lung heterogeneities in ventilation and perfusion, 4) Skeletal muscle bioenergetics, and 5) Mitochondrial reactive oxygen species (ROS) generation. These models will be written in systems biology markup language (SBML) and vertically integrated. Ontologies will be used as the default knowledge-representation system. The KB will include multi-level data from experimental studies (BioBridge), data from a multicentre longitudinal study on COPD phenotyping (PAC-COPD) and public datasets.The IE will enable to explore associations over the KB, perform transversal multi-scale model integration and related simulations including interactions among O2-availability/O2-utilization, ROS generation, systemic inflammation and abnormal tissue remodelling.The Web-based GVE will facilitate relevant simulations in a more intuitive way with respect to the state of the art, addressing two main user profiles: bio-researchers and clinicians.The focus will be on underlying mechanisms of COPD phenotypes associated with poor prognosis. Disease model validation and refinement will be done using a well-established, large dataset (ECLIPSE) together with experimental studies designed to test "in silico" generated hypotheses. Besides the use of the simulation environment by bio-researchers for optimal experimental design, the Synergy platform will be a relevant decision-support tool for integrated healthcare strategies aiming at modulating the evolution of COPDs. Fields of science natural sciencescomputer and information sciencesknowledge engineeringontology Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2009.5.3 - Virtual Physiological Human Call for proposal FP7-ICT-2009-6 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator FUNDACIO PRIVADA BARCELONA DIGITAL CENTRE TECNOLOGIC EU contribution € 801 928,00 Address CARRER ROC BORONAT 117, 5 PLANTA 08018 Barcelona Spain See on map Activity type Research Organisations Administrative Contact Maria Sanchez Moreno (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOMAX INFORMATICS AG Germany EU contribution € 430 380,00 Address ROBERT KOCH STRASSE 2 82152 STEINKIRCHEN See on map Region Bayern Oberbayern München, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Dieter Maier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LINKCARE HEALTH SERVICES SL Spain EU contribution € 181 242,00 Address CALLE ROGER DE LLURIA 50, SaT A 08009 Barcelona See on map Region Este Cataluña Barcelona Administrative Contact Mercedes Guerrero (Ms.) Links Contact the organisation Opens in new window Total cost No data CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 577 144,00 Address CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martínez Samper (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM Hungary EU contribution € 125 400,00 Address MUEGYETEM RAKPART 3 1111 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact János Kertész (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 558 688,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 306 987,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Polik (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF BIRMINGHAM Participation ended United Kingdom EU contribution € 120 526,00 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Administrative Contact Robert Fekete (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 106 090,00 Address BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Catherine Cowton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INFERMED LIMITED United Kingdom EU contribution € 285 615,00 Address BEDFORD SQUARE 25 WC1B 3HW LONDON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alan Montgomery (Dr.) Links Contact the organisation Opens in new window Total cost No data