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Role of Adipocytokines in the Appearance & Development of Chronic Cardiac Insufficiency in Patients with Postinfarction Cardiosclerosis & Type 2 DM

Contributed by: Kharkov National Medical University

Adipocytokines play an important role in the appearance and development of cardiovascular diseases and diabetes mellitus, along with their complications due to immune inflammation and insulin resistance. Omentin and vaspin are new and insufficiently studied fat tissue hormones. Nevertheless, there are already rare reports about the roles of these adipokines in various disease pathogeneses. Studies are still going on because the omentin and vaspin roles in chronic cardiac insufficiency.
Complex examination of 68 patients with CCI was carried out. All the CCI cases had emerged on the background of postinfarction cardiosclerosis and type 2 DM. 35 healthy persons were included into the control group. The vaspin and omentin contents in blood serum were identified using the immune-enzyme analysis method.

In the course of CCI development from functional class II to functional class IV, the probable rise of the vaspin level (614.246±2.219 pg/mL; 631.328±2.193 pg/mL, and 654.428±2.263 pg/mL, respectively) and reduction of the omentin level (419.936±1.215 ng/mL; 408.567±1.191 ng/mL, and 396.354±1.224 ng/mL, respectively) occur (p<0.001).

The vaspin level in patients of the treatment group with ejection fraction > 45 % occurred to be 611.343 pg/mL which was lover by 6 % as compared to patients with ejection fraction < 45 % (649.572 pg/mL) (p<0.001). The omentin level in patients with the left ventricle systolic function retained was equal to 425.131 ng/mL which is higher, by 4.5 %, as compared to patients with left ventricle systolic dysfunction (406.312 ng/mL) (p<0.001).

Vaspin and omentin levels are important for CCI development in patients with postinfarction cardiosclerosis and type 2 DM.

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    Kharkov National Medical University
    Nauki avenue,4
    61022 Kharkov
    Ukraine
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  • Ukraine

Keywords

chronic cardiac insufficiency, postinfarction cardiosclerosis, type 2 diabetes mellitus, vaspin, omentin, omentyn
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