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The Role of Adipocytokines in the Development and Progression of Chronic Heart Failure in Postinfarction Cardiosclerosis, Type 2 DM and Obesity

Contributed by: Kharkov National Medical University

Over the past few years, the researchers have defined the pathogenic role of some adipokines in the mechanisms of development and progression of obesity, diabetes, insulin resistance and cardiovascular diseases.
Study target – to assess adipocytokines role in the development and progression of chronic heart failure in postinfarction cardiosclerosis, Type 2 diabetes mellitus and obesity patients.

We comprehensively examined 71 patients with chronic heart failure (CHF) that appeared on the grounds of postinfarction cardiosclerosis and Type 2 diabetes mellitus (DM). The control group included 35 almost healthy subjects. Vaspin and Omentin content in blood serum was determined by the ELISA test. In functional class (FC) II CHF patients Vaspin content was 809.431 ± 3.647 pg/ml, which was by 1.57% and 3.2% lower than in FC III and IV CHF patients, where the value was equal to 822.375 ± 3.291 pg/ml and 836.289 ± 3.418 pg/ml, respectively (p<0.001).

The omentin content in FC II CHF patients was 303.942 ± 2.134 ng/ml, which was by 4.73% and 7.47% higher than in FC III and IV CHF patients, where the value was equal to 289.564 ± 2.297 ng/ml and 281.238 ± 2.168 ng/ml, respectively (p<0.001). An adipocytokines content analysis conducted in postinfarction cardiosclerosis, Type 2 DM and obesity patients, depending on ejection fraction (EF), showed significant Vaspin increase in patients with left ventricular (LV) systolic dysfunction (LV) to 849.472 pg/ml as compared to the patients with EF>45% (821.674 pg/ml) and Omentin reduction to 284.873 ng/ml as compared to 318.691 ng/ml in patients with preserved LV systolic function (p<0.05).

Conclusions: CHF functional class increase was associated with adipocytic dysfunction in postinfarction cardiosclerosis, Type 2 diabetes mellitus and obesity patients, which was defined by hipervaspinemia and hipoomentinemia. Boosted Vaspin content and decreased Omentin content causes systolic dysfunction in postinfarction cardiosclerosis, Type 2 diabetes mellitus and obesity patients.

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    Kharkov National Medical University
    Nauki avenue,4
    61022 Kharkov
    Ukraine
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  • Ukraine

Keywords

chronic heart failure, Vaspin, Omentin, obesity, Type 2 diabetes mellitus., omentyn
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