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The Role of Adipose Tissue Hormones in the Pathogenesis of Obesity in Patients with Postinfarction Cardiosclerosis

Contributed by: Kharkov National Medical University

According to many authors, adipose tissue hormones play a significant role in the development and progression of cardiovascular disease, obesity and diabetes.
A comprehensive examination of 76 patients after myocardial infarction with various localisation for the past 1 - 5 years with concomitant obesity was performed. The comparison group consisted of 80 patients with postinfarction cardiosclerosis without obesity. The control group comprised 35 apparently healthy individuals. ELISA was used to determine serum vaspin and omentin in the patients.

Findings: Vaspin levels in patients with postinfarction cardiosclerosis and obesity were significantly higher, 20.56 % and 63.84 % compared with subjects with normal weight and the control group, and were 531.533±4.536 pg/ml; 422.278±3.195 pg/ml and 192.207±2.126 pg/ml respectively (р<0.001), while omentin levels in patients of the study group (445.416±3.054 ng/ml) were significantly higher, 14.29 % and 20.44 %, compared with subjects who were not obese and the control group, where they were 519.657±1.321 ng/ml and 559.838±1.362 ng/ml respectively (р<0.001).

Conclusion: Vaspin and omentin levels play an important role in the development of obesity in patients with postinfarction cardiosclerosis.

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    Kharkov National Medical University
    Nauki avenue,4
    61022 Kharkov
    Ukraine
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  • Ukraine

Keywords

vaspin, omentin, obesity, postinfarction cardiosclerosis, omentyn
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