Objective
Recent data suggest the placebo effect to be a powerful demonstration of how mental activity that is shaped by expectation and experience can influence physiological functions. The current strategy to minimize potential placebo effects largely ignores the positive effects of the placebo response. The current proposal postulates a radically different approach: Instead of considering placebo effects a nuisance, we will explicitly investigate the mechanisms behind expectation and experience (i.e. placebo response) to develop its use for the benefit of the patient. Importantly, the same applies to the effect of negative expectations (i.e. nocebo response) that can be responsible for negative effects of treatment. Understanding the mechanisms and circumstances that promote these effects will allow us to adjust medical treatments to minimize these nocebo effects. We will investigate the mechanisms of placebo and nocebo responses in traditional fields such as pain, but also in respiratory medicine and in “cognitive enhancement”. Using functional magnetic resonance imaging (fMRI), pharmacological interventions and formal models we will in particular address the neuronal mechanisms underlying placebo and nocebo responses. Combining the data from all three fields (pain, respiration and cognitive enhancement) will allow us to identify domain general and domain specific mechanisms of placebo responses. These projects will be supported by a methodological work-package which will provide neuroimaging techniques to improve the assessment of placebo and nocebo relevant brain structures. Finally a large cohort of volunteers will be investigated, to assess the relationship between placebo responses, personality variables and genetic polymorphisms using a genome-wide association analysis. Insights gained in this project could have the potential to formally place placebo responses and related mechanisms such as experience and expectation into the mainstream of evidence based medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine pneumology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-AdG_20100407
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
20251 Hamburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.