Objective
Type 2 diabetes and cancer are two chronic diseases that negatively influence the survival of millions of people worldwide. Diabetes has been shown in meta-analyses to be associated with an increased risk of several cancers, but these associations are not yet documented as causal. The evidence for specific diabetes drugs affecting cancer risk is limited, because randomized clinical trials are not designed to evaluate specifically cancer outcomes, and observational studies are often confounded by indications for specific drugs. We propose to better characterize the degree of involvement of type 2 diabetes diagnosis and pharmacologic treatment in cancer initiation or progression. Therefore, we will a) evaluate bias and credibility in the existing meta-analyses of diabetes diagnosis and cancer risk, b) determine whether diabetes diagnosis is associated with risk of prostate cancer using the European Prospective Investigation into Cancer and Nutrition cohort, c) perform a systematic review and meta-analysis of randomized clinical trials and observational studies that have evaluated the association between diabetes medications and cancer risk, and d) evaluate the association between diabetes drugs and cancer risk (separately by site) using the UK-based General Practice Research Database. Cutting-edge evidence synthesis methods (Harbord’s test, excess significance bias test, credibility ceilings) will be used in our first aim, and summary meta-analytic estimates will be calculated in our third aim using random effects models. An incident diabetes drug cohort design with adherence-adjusted intention-to-treat style of analysis will be used in aim 4, while Cox proportional hazards models will be used in both aims 2 and 4. The proposed project will have major impact in the field, because the literature on diabetes diagnosis, treatment on cancer risk will be properly evaluated, and these associations will be further assessed in two large, unique prospective studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine oncology prostate cancer
- natural sciences computer and information sciences databases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences health sciences nutrition
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
45 110 IOANNINA
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.