Objective
Computational mechanics techniques have revolutionised the design and analysis of engineered structures. The emerging field of Computational Biomechanics (CB) applies these techniques to study biological structures and systems. A key advantage of CB is the ability to predict physical quantities (such as flow and deformation) over a range of length and timescales in biological tissues, whereas such quantities are difficult or impossible to measure experimentally in living organisms.
This project will develop multiscale CB approaches to analyse the largest avascular structure in the human body, the intervertebral disc. The intervertebral disc is subjected to large deformations during spinal motion, withstands transient loads of up to 9 times body weight during rigorous physical activity, and due to its lack of blood supply, its nutrient supply is provided by fluid-borne diffusion through the disc tissues from the adjacent vertebral bodies. A multiscale model of the intervertebral disc will substantially advance the study of disc mechanics by linking whole disc loading and deformation to the mechanical microenvironment experienced by cells embedded within the disc tissue. This approach promises new insights into tissue repair and remodelling in healthy discs, into tissue damage and cell death in degenerate discs, and in predicting disc response to emerging treatments such as annular repair and nucleus replacement.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75013 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.