Objective
A fundamental goal of neuroscience is to understand how information processing in neural circuits gives rise to behavior. Even the simplest actions can involve hundreds of neurons distributed throughout the brain. However, for most behaviors, little is known about which neurons play an important role, how they are organized into circuits, or how activity is transformed between different brain areas. The zebrafish model provides a unique opportunity to thoroughly dissect the neural basis of behavior in a vertebrate, due to their small, transparent brains, robust visual responses, and amenability to genetic manipulation. Using two-photon imaging, we can scan the entire area of the brain while monitoring the activity of individual neurons. This research programme aims to dissect the circuits underlying simple visually guided behaviors in larval zebrafish using a combination of state-of-the-art imaging, genetics and behavioral analysis. We propose to 1) perform a quantitative analysis of zebrafish behavior using high speed videography, and a custom designed arena for presentation of visual stimuli to freely swimming fish, 2) identify individual neurons and circuits that are active during these behaviors using two-photon imaging of fish expressing genetically encoded calcium indicators to and 3) perturb activity in these circuits using targeted single cell laser ablations and optogenetics. These experiments will map out the functional architecture of the zebrafish brain, revealing sets of neurons that comprise complete behavioral circuits in a vertebrate. Furthermore, they will provide an essential framework for the analysis of neural development, genetic mutants and disease models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences medical biotechnology genetic engineering
- natural sciences computer and information sciences data science data processing
- natural sciences physical sciences optics laser physics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
1400-038 LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.