Objectif Antibodies are a critical component of immune defence but they provide purely extracellular protection – once inside a cell, a pathogen is safe. This is the view of humoral immunity that has existed for over 100 years. However, recent work in my lab has led to the discovery of a missing system of antibody-mediated immunity that takes place inside infected cells. I have identified a novel cytosolic antibody receptor (TRIM21) that binds to antibody-coated viruses after cellular infection and targets them for degradation in the proteasome. Importantly, TRIM21-mediated immunity is capable of clearing a cell of virus within hours of infection. This discovery represents a paradigm shift in how we think about viral immunity and offers the potential for new types of antiviral drugs.This grant application outlines key experiments to determine how intracellular antibody immunity works, what it works against and how we can augment or replicate it in the treatment of disease. Champ scientifique natural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS6 - ERC Starting Grant - Immunity and infection Appel à propositions ERC-2011-StG_20101109 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil MEDICAL RESEARCH COUNCIL Contribution de l’UE € 1 124 340,00 Adresse 20 Park Crescent W1B 1AL LONDON Royaume-Uni Voir sur la carte Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Elizabeth Cutler (Ms.) Chercheur principal Leo James (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MEDICAL RESEARCH COUNCIL Royaume-Uni Contribution de l’UE € 1 124 340,00 Adresse 20 Park Crescent W1B 1AL LONDON Voir sur la carte Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Elizabeth Cutler (Ms.) Chercheur principal Leo James (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée