Objectif Ubiquitin (Ub) is a 76 amino acid protein that is commonly found in isopeptide linkage to a lysine residue of a target protein. This post-translational modification controls most cellular processes, including DNA repair, trafficking and protein degradation. Ubiquitin conjugation onto any of its 7 own lysine residues or onto its N-terminus results in a large number of differently linked polymers; the shape, charge and size of which determine how they interact with ubiquitin binding domains (UBDs). Binding to proteins containing such domains triggers further events that determine the fate of a Ub-tagged substrate in subsequent biochemical events in a Ub chain topology dependent manner. Malfunction of these signal transduction events contributes to the pathology of human disease. Although all Ub linkages are found in cells and all likely have specific functions, only few of them have been intensively studied so far as most linkages cannot be generated biochemically.This project will investigate how Ub linkages are recognized by UBDs to transduce cellular signals in a chain specific manner, including all linkages with all their possible topoisomers. This information will then be used to generate pharmacological modulators aimed at interfering with specific UBD-mediated signal transduction events. Champ scientifique natural sciencesbiological sciencesgeneticsDNAnatural sciencesmathematicspure mathematicstopologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural scienceschemical sciencespolymer sciencesnatural scienceschemical sciencesorganic chemistryamines Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS1 - ERC Starting Grant - Molecular and Structural Biology and Biochemistry Appel à propositions ERC-2011-StG_20101109 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil ACADEMISCH ZIEKENHUIS LEIDEN Contribution de l’UE € 42 179,00 Adresse ALBINUSDREEF 2 2333 ZA Leiden Pays-Bas Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Type d’activité Higher or Secondary Education Establishments Chercheur principal Huib Ovaa (Dr.) Contact administratif Michael Van Harmelen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ACADEMISCH ZIEKENHUIS LEIDEN Pays-Bas Contribution de l’UE € 42 179,00 Adresse ALBINUSDREEF 2 2333 ZA Leiden Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Type d’activité Higher or Secondary Education Establishments Chercheur principal Huib Ovaa (Dr.) Contact administratif Michael Van Harmelen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Participation terminée Pays-Bas Contribution de l’UE € 1 456 061,00 Adresse PLESMANLAAN 121 1066 CX Amsterdam Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Research Organisations Contact administratif Henri Van Luenen (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée