Objective
The differentiation of the male and female genital phenotype is established at 7-12 weeks post conception. During this period, maintaining the appropriate intrauterine hormone environment is essential. However, it is surprising how little is known about the intrauterine hormonal milieu and the consequences of hormonal alterations. During her Marie Curie Intra-European Fellowship Dr Reisch’s work provided conclusive evidence for the existence of a novel androgen pathway in the fetal adrenal and its significance for the pathophysiology of oxidoreductase deficiency (ORD), a recently described form of congenital adrenal hyperplasia (CAH). The virilisation observed in CAH due to 21-hydroxylase deficiency (21-OHD), the most common form of CAH affecting 1:10,000 newborns, intricately ties the function of the fetal adrenal cortex to sexual differentiation of the external genitalia. To date, this has been explained by excessive production of adrenal androgens via the classic pathway to androgen synthesis during fetal and postnatal life. However, during fetal life, it is highly likely that the novel alternative pathway also plays a significant role in the pathogenesis of 21-OHD. The research of this grant application will investigate the impact of the newly discovered alternative pathway to fetal androgen biosynthesis on virilisation in 21-OHD via the analysis of the steroid metabolome in urines of pregnant mothers carrying babies affected with 21-OHD and affected newborns. Secondly, the project will elucidate the impact of the fetal adrenal-gonadal hormonal cross-talk on the development of testicular and ovarian adrenal rest tumors in 21-OHD in a model of 21-OHD deficient mice. These tumors are the most common cause of infertility in 21-OHD and current data suggest that they are primed during fetal development. This project has the potential of transfer of the results into patient care, e.g. with regard to refinement of prenatal treatment of CAH patients in the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine obstetrics fetal medicine
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.