Objective Epilepsies are chronic disorders with a prevalence of 1% worldwide including Europe; they severely affect the quality of life of patients, especially of those (one third) who are drug-resistant. They are multifactorial disorders sharing common pathophysiological mechanisms among which dysfunctions in voltage-gated and ligand-gated (receptors) ion channels and alterations in structure and function of neuronal networks play a major role. This project will identify disease-causing genes and their functional role in the pathophysiology of neuronal excitability and network synchronization, using complementary advanced methods. The work will be focused on voltage-gated Na+ channels and GABAergic synaptic inhibition. Their crucial epileptogenic role is recognized for both inherited acquired epilepsies and will be investigated in animal models and human tissue with a focus on drug resistant temporal lobe epilepsy and epilepsies due to developmental cortical abnormalities. A main effort is devoted to investigate developmental aspects of epileptogenesis that account for the high frequency of epilepsies in children and for their often severe prognosis. Strictly related to the above research lines are the pharmacological approaches by which EPICURE aims at developing more effective antiepileptic strategies, at understanding the biological bases of pharmacoresistance and at evaluating the potential of innovative therapeutic approaches based on synaptic modulation by neurotrophic factors and cell cycle kinase inhibitors. Despite the internationally recognized role of epilepsy research in Europe, the leading research groups lack a central coordination to take advantage of cross-fertilization and synergistic effects. EPICURE intends to bring together expertise from different research areas both clinical and laboratory-based with the common goal of advancing European epilepsy research to bring about novel therapeutic benefits to patients. Fields of science medical and health sciencesbasic medicineneurologyepilepsynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2005-2.1.3-2 - Functional genomics and neurobiology of epilepsy Call for proposal FP6-2005-LIFESCIHEALTH-6 See other projects for this call Funding Scheme IP - Integrated Project Coordinator FONDAZIONE IRCCS ISTITUTO NEUROLOGICO "CARLO BESTA" EU contribution No data Address Via Giovanni Celoria 11 MILANO Italy See on map Links Website Opens in new window Total cost No data Participants (32) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTÉ ET RECHERCHE MÉDICALE France EU contribution No data Address 101 rue de Tolbiac PARIS See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DEGLI STUDI DI VERONA Italy EU contribution No data Address Via dell'Artigliere 8 VERONA See on map Links Website Opens in new window Total cost No data FRIEDRICH ALEXANDER UNIVERSITY OF ERLANGEN-NURNBERG Germany EU contribution No data Address Schlossplatz 4 ERLANGEN See on map Links Website Opens in new window Total cost No data MAGYAR TUDOMANYOS AKADEMIA KISERLETI ORVOSTUDOMANYI KUTATOINTEZET Hungary EU contribution No data Address Szigony 43 BUDAPEST See on map Links Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM BONN Germany EU contribution No data Address Sigmund-Freud Str. 25 BONN See on map Links Website Opens in new window Total cost No data CHARITÉ UNIVERSITATMEDIZIN BERLIN Germany EU contribution No data Address Luisenstr. 21-23 BERLIN See on map Links Website Opens in new window Total cost No data LUNDS UNIVERSITET Sweden EU contribution No data Address Paradisgatan 2 117 LUND See on map Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution No data Address Heidelberglaan 100 85600 UTRECHT See on map Links Website Opens in new window Total cost No data HELSINGIN YLIOPISTO Finland EU contribution No data Address Yliopistonkatu 4 HELSINKI See on map Links Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM ULM Germany EU contribution No data Address Albert-Einstein-Allee 29 ULM See on map Links Website Opens in new window Total cost No data JOHANNES GUTENBERG UNIVERSITAET MAINZ Germany EU contribution No data Address Saarstrasse 21 MAINZ See on map Links Website Opens in new window Total cost No data ISTANBUL UNIVERSITESI Türkiye EU contribution No data Address Vakif Gureba Caddesi Capa ISTANBUL See on map Links Website Opens in new window Total cost No data FONDAZIONE ISTITUTO NEUROLOGICO NAZIONALE CASIMIRO MONDINO Italy EU contribution No data Address Via Mondino 2 PAVIA See on map Links Website Opens in new window Total cost No data ITÄ-SUOMEN YLIOPISTO Finland EU contribution No data Address YLIOPISTONRANTA I E 1627 KUOPIO See on map Links Website Opens in new window Total cost No data PHILIPPS-UNIVERSITAET MARBURG Germany EU contribution No data Address Biegenstrasse 10 MARBURG See on map Total cost No data FUNDACIÓN JIMÉNEZ DÍAZ UTE Spain EU contribution No data Address Avda. Reyes Católicos, 2 MADRID See on map Links Website Opens in new window Total cost No data UNIVERSITÀ DEGLI STUDI DI FERRARA Italy EU contribution No data Address via Savonarola 9 FERRARA See on map Links Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAT INNSBRUCK Austria EU contribution No data Address Christoph Probst Platz 1 INNSBRUCK See on map Links Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower Street LONDON See on map Links Website Opens in new window Total cost No data ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy EU contribution No data Address via La Masa 19 MILANO See on map Total cost No data ISTITUTO GIANNINA GASLINI Italy EU contribution No data Address Largo Gerolamo Gaslini, 5 GENOVA See on map Links Website Opens in new window Total cost No data OZ BIOSCIENCES France EU contribution No data Address PARC SCIENTIFIQUE ET TECHNOLOGIQUE DE LUMINY MARSEILLE See on map Links Website Opens in new window Total cost No data ILERI TIP TEKNOLOJILERI DAN. HIZM. SAN. TIC. LTD. STI. Türkiye EU contribution No data Address Tavukcuyolu Cad. Acun Sok. No: 54/18 / Cakmak Umraniye ISTANBUL See on map Links Website Opens in new window Total cost No data NSGENE A/S Denmark EU contribution No data Address 154 Baltorpvej BALLERUP See on map Links Website Opens in new window Total cost No data NEUROKIN SARL France EU contribution No data Address INMED, Parc Scientifique de Luminy MARSEILLE See on map Total cost No data BRAINWAVE, THE IRISH EPILEPSY ASSOCIATION Ireland EU contribution No data Address 249 Crumlin Road DUBLIN See on map Links Website Opens in new window Total cost No data CF CONSULTING FINANZIAMENTI UNIONE EUROPEA S.R.L. Italy EU contribution No data Address Via Giuseppe Mussi 1 MILANO See on map Links Website Opens in new window Total cost No data AZIENDA OSPEDALIERO UNIVERSITARIA MEYER Italy EU contribution No data Address via Luca Giordano n. 7/M FIRENZE See on map Links Website Opens in new window Total cost No data KLINIKUM DER UNIVERSITÄT ZU KÖLN Germany EU contribution No data Address Kerpener Str. 62 COLOGNE See on map Links Website Opens in new window Total cost No data BIOCODEX France EU contribution No data Address Avenue Galliéni 7 GENTILLY See on map Links Website Opens in new window Total cost No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution No data Address Geschwister-Scholl-Platz 1 TUEBINGEN See on map Links Website Opens in new window Total cost No data UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ Germany EU contribution No data Address Langenbeckstr. 1 MAINZ See on map Links Website Opens in new window Total cost No data