Objective
This proposal will elucidate the circuit mechanism that underlies the spatial memory-related information processing in the interconnected brain areas of the hippocampus and entorhinal cortex (EC). Both of these areas are implicated in spatial memory and encode spatial information in neuronal activity patterns. The mechanisms underlying the emergence and coordination of spatial memory-related activity in these regions are needed to understand how these circuits process mnemonic information. Accordingly, here we aim at elucidating the representation of spatial memory by investigating these mechanisms at the circuit and synaptic levels of organisation. The first objective of this proposal is to characterise oscillatory synchronisation in hippocampo-EC circuits at different stages of memory processing. We hypothesise that network oscillations facilitate circuit interactions during memory processing. Therefore, using optogenetic techniques to disrupt oscillations, we aim at identifying critical periods during mnemonic processing when synchronisation is needed. Secondly, we intend to reveal how mnemonic information is encoded and exchanged between different areas of the hippocampo-EC system. We will test whether spatial memory-associated firing of dorsal hippocampal cells could be triggered by EC and/or ventral hippocampal cells that encode similar mnemonic features. In addition, this project will explore the role of temporal coding in the representation and consolidation of spatial memory traces. The third objective will investigate synaptic changes between connected CA3-CA3 and CA3-CA1 cell pairs during spatial learning. We will use cross-correlation analysis and electrical microstimulation to examine the rules that govern changes in synaptic efficacy by observing the probability of spike transmission.
Overall, the proposal provides a comprehensive approach to understanding how hippocampo-EC circuits organise and store information during mnemonic processes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
3400 KLOSTERNEUBURG
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.