Objective
The development of therapeutic vaccines often includes the use of synthetic small molecule antigen constructs to elicit immune response. However, many subunit antigen vaccines are less immunogenic than those employing attenuated microorganisms. As a result, they often require co-administration with an adjuvant or immunostimulating complex, a substance that is itself not necessarily immunogenic but functions in concert with the antigen to enhance/prolong immune response. Whereas the design of subunit antigen constructs has played an influential role in the development of clinically viable vaccine therapies, efficacy modulation of vaccines through the design and chemical synthesis of distinct molecular adjuvants has been comparatively less common given the structural complexity of these substances. With the aid of several chemical glycosylation methodologies developed in Professor Gin laboratories, the first synthesis and structure verification of several complex triterpene saponins have been achieved. Through collaborations with immunologists and clinicians, current efforts are also devoted to the generation of designed structural analogs for the development of more powerful and stable adjuvants for both anti-cancer and anti-viral therapeutic vaccines. At a final stage, recent progress made in Professor Jiménez-Barbero group on the application of NMR methods to study the structural and recognition properties of carbohydrates will allow us to gain insights into the conformational behavior and the immunostimulating activity of these newly synthesized adjuvants. Thus, we will carry out advanced NMR experiments to assess the conformational features and aggregation properties of these compounds . As a consequence, we are in a unique position to conduct systematic structure-activity investigations on this class of natural product with the goal of unraveling its as yet unknown mechanism of immunostimulatory activity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences microbiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.