Objetivo The importance of carbon-based materials in biological applications has been recognized. Especially, nanodiamond particles (referred to as nanodiamonds, NDs) have started to emerge as novel candidate for promising applications in the field of nano-biotechnology as imaging probes and drug carriers. NDs do not show the toxicity of other nanoparticles, notably gold, making them ideal nanoscale drug delivery platforms. Furthermore, NDs can exhibit intrinsic fluorescence from point defects making them candidates for biomedical imaging applications. ND particles are particularly attractive for biomedical applications as functionalization and biomolecule immobilization are readily accomplished. Triggered drug release allows the functionalized NDs to find their targets before the drugs are activated by local conditions. In this sense, the NDs are performing the well established role of postdrugs, smuggeling the inactive compound to their targets where they are released through bond cleavage.The objective of the proposed program concerns the fabrication of NDs modified with photo-label linkers where different molecules can be directly attached, without chemically modification of the biomolecule itself. In a proof of principle, horse radish peroxidase (HRP) will be linked to NDs modified with the photo-label o-nitrobenzyl group and the release followed by UV/Vis. In a later state the controlled release of drugs such as ibuprofen, adriamycin or antigens will be looked at.The proposed research project brings together centers from France, the UK, Spain and the Ukrain. The network offers training in the fabrication and characterization of new materials for biological applications. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesengineering and technologynanotechnologynano-materials Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2010-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Convocatoria de propuestas FP7-PEOPLE-2010-IRSES Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IRSES - International research staff exchange scheme (IRSES) Coordinador UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE I Aportación de la UE € 66 500,00 Dirección CITE SCIENTIFIQUE 59655 VILLENEUVE D'ASCQ Francia Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Sabine Szunerits (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF BRIGHTON Reino Unido Aportación de la UE € 47 500,00 Dirección LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton Ver en el mapa Región South East (England) Surrey, East and West Sussex Brighton and Hove Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Peter Cragg (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITE DE PICARDIE JULES VERNE Francia Aportación de la UE € 36 100,00 Dirección CHEMIN DU THIL 80025 Amiens Ver en el mapa Región Hauts-de-France Picardie Somme Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Veaceslav Grosu (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS España Aportación de la UE € 20 900,00 Dirección CALLE SERRANO 117 28006 Madrid Ver en el mapa Región Comunidad de Madrid Comunidad de Madrid Madrid Tipo de actividad Research Organisations Contacto administrativo Eusebio Jiménez Arroyo (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSIDAD DE SEVILLA España Aportación de la UE € 15 200,00 Dirección CALLE S. FERNANDO 4 41004 Sevilla Ver en el mapa Región Sur Andalucía Sevilla Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Margarita Martinez-Pais Loscertales (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos