Objectif The importance of carbon-based materials in biological applications has been recognized. Especially, nanodiamond particles (referred to as nanodiamonds, NDs) have started to emerge as novel candidate for promising applications in the field of nano-biotechnology as imaging probes and drug carriers. NDs do not show the toxicity of other nanoparticles, notably gold, making them ideal nanoscale drug delivery platforms. Furthermore, NDs can exhibit intrinsic fluorescence from point defects making them candidates for biomedical imaging applications. ND particles are particularly attractive for biomedical applications as functionalization and biomolecule immobilization are readily accomplished. Triggered drug release allows the functionalized NDs to find their targets before the drugs are activated by local conditions. In this sense, the NDs are performing the well established role of postdrugs, smuggeling the inactive compound to their targets where they are released through bond cleavage.The objective of the proposed program concerns the fabrication of NDs modified with photo-label linkers where different molecules can be directly attached, without chemically modification of the biomolecule itself. In a proof of principle, horse radish peroxidase (HRP) will be linked to NDs modified with the photo-label o-nitrobenzyl group and the release followed by UV/Vis. In a later state the controlled release of drugs such as ibuprofen, adriamycin or antigens will be looked at.The proposed research project brings together centers from France, the UK, Spain and the Ukrain. The network offers training in the fabrication and characterization of new materials for biological applications. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesengineering and technologynanotechnologynano-materials Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Appel à propositions FP7-PEOPLE-2010-IRSES Voir d’autres projets de cet appel Régime de financement MC-IRSES - International research staff exchange scheme (IRSES) Coordinateur UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE I Contribution de l’UE € 66 500,00 Adresse CITE SCIENTIFIQUE 59655 VILLENEUVE D'ASCQ France Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Sabine Szunerits (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF BRIGHTON Royaume-Uni Contribution de l’UE € 47 500,00 Adresse LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton Voir sur la carte Région South East (England) Surrey, East and West Sussex Brighton and Hove Type d’activité Higher or Secondary Education Establishments Contact administratif Peter Cragg (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITE DE PICARDIE JULES VERNE France Contribution de l’UE € 36 100,00 Adresse CHEMIN DU THIL 80025 Amiens Voir sur la carte Région Hauts-de-France Picardie Somme Type d’activité Higher or Secondary Education Establishments Contact administratif Veaceslav Grosu (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Espagne Contribution de l’UE € 20 900,00 Adresse CALLE SERRANO 117 28006 Madrid Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Research Organisations Contact administratif Eusebio Jiménez Arroyo (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSIDAD DE SEVILLA Espagne Contribution de l’UE € 15 200,00 Adresse CALLE S. FERNANDO 4 41004 Sevilla Voir sur la carte Région Sur Andalucía Sevilla Type d’activité Higher or Secondary Education Establishments Contact administratif Margarita Martinez-Pais Loscertales (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée