Obiettivo The importance of carbon-based materials in biological applications has been recognized. Especially, nanodiamond particles (referred to as nanodiamonds, NDs) have started to emerge as novel candidate for promising applications in the field of nano-biotechnology as imaging probes and drug carriers. NDs do not show the toxicity of other nanoparticles, notably gold, making them ideal nanoscale drug delivery platforms. Furthermore, NDs can exhibit intrinsic fluorescence from point defects making them candidates for biomedical imaging applications. ND particles are particularly attractive for biomedical applications as functionalization and biomolecule immobilization are readily accomplished. Triggered drug release allows the functionalized NDs to find their targets before the drugs are activated by local conditions. In this sense, the NDs are performing the well established role of postdrugs, smuggeling the inactive compound to their targets where they are released through bond cleavage.The objective of the proposed program concerns the fabrication of NDs modified with photo-label linkers where different molecules can be directly attached, without chemically modification of the biomolecule itself. In a proof of principle, horse radish peroxidase (HRP) will be linked to NDs modified with the photo-label o-nitrobenzyl group and the release followed by UV/Vis. In a later state the controlled release of drugs such as ibuprofen, adriamycin or antigens will be looked at.The proposed research project brings together centers from France, the UK, Spain and the Ukrain. The network offers training in the fabrication and characterization of new materials for biological applications. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesengineering and technologynanotechnologynano-materials Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2010-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Invito a presentare proposte FP7-PEOPLE-2010-IRSES Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IRSES - International research staff exchange scheme (IRSES) Coordinatore UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE I Contributo UE € 66 500,00 Indirizzo CITE SCIENTIFIQUE 59655 VILLENEUVE D'ASCQ Francia Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Sabine Szunerits (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF BRIGHTON Regno Unito Contributo UE € 47 500,00 Indirizzo LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton Mostra sulla mappa Regione South East (England) Surrey, East and West Sussex Brighton and Hove Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Peter Cragg (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITE DE PICARDIE JULES VERNE Francia Contributo UE € 36 100,00 Indirizzo CHEMIN DU THIL 80025 Amiens Mostra sulla mappa Regione Hauts-de-France Picardie Somme Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Veaceslav Grosu (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE € 20 900,00 Indirizzo CALLE SERRANO 117 28006 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Research Organisations Contatto amministrativo Eusebio Jiménez Arroyo (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD DE SEVILLA Spagna Contributo UE € 15 200,00 Indirizzo CALLE S. FERNANDO 4 41004 Sevilla Mostra sulla mappa Regione Sur Andalucía Sevilla Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Margarita Martinez-Pais Loscertales (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato