Objective
Genetic sequences have had an enormous impact on our understanding of biology. The expectation is that biological network data will have a similar impact. However, progress is hindered by a lack of sophisticated graph theoretic tools that will mine these large networked datasets.
In recent breakthrough work at the boundary of computer science and biology supported by my USA NSF CAREER award, I developed sensitive network analysis, comparison and embedding tools which demonstrated that protein-protein interaction networks of eukaryotes are best modeled by geometric graphs. Also, they established phenotypically validated, unprecedented link between network topology and biological function and disease. Now I propose to substantially extend these preliminary results and design sensitive and robust network alignment methods that will lead to uncovering unknown biology and evolutionary relationships. The potential ground-breaking impact of such network alignment tools could be parallel to the impact the BLAST family of sequence alignment tools that have revolutionized our understanding of biological systems and therapeutics. Furthermore, I propose to develop additional sophisticated graph theoretic techniques to mine network data and hence complement biological information that can be extracted from sequence. I propose to exploit these new techniques for biological applications in collaboration with experimentalists at Imperial College London: 1. aligning biological networks of species whose genomes are closely related, but that have very different phenotypes, in order to uncover systems-level factors that contribute to pronounced differences; 2. compare and contrast stress response pathways and metabolic pathways in bacteria in a unified systems-level framework and exploit the findings for: (a) bioengineering of micro-organisms for industrial applications (production of bio-fuels, bioremediation, production of biopolymers); (b) biomedical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences mathematics pure mathematics topology
- natural sciences computer and information sciences
- engineering and technology electrical engineering, electronic engineering, information engineering information engineering telecommunications telecommunications networks
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101014
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
WC1E 6BT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.