Objective NANORESISTANCE introduces for the first time (i) receptor -independent targeting of Epidermal Growth Factor Receptor-kinase activity, (ii) nuclear delivery of anti-Epidermal Growth Factor Receptor therapy with novel grafting techniques and (iii) the deciphering of resistance and lack of responsiveness to anti-EGFR therapies in the preclinical setting with mathematical models of interstitial biodistribution. This work defines an unprecedented integrated approach for the comprehensive management of failure to anti-EGFR therapy and treatment monitoring. This partnership will play a structuring role by allowing researchers to acquire key skills equally relevant to the public and private sectors including cutting edge nanobiotechnology techniques for fabrication of nanotheranostic conjugates for targeted nuclear drug delivery and imaging, pioneering approaches for intracellular targeting with carbon nanotubes (CNT), innovative mathematical models and assessment of biodistribution, state-of-the-art Surface Plasmon Resonance for assessing drug-target interactions, emerging technologies for in vivo protein-protein and theranostic compound-protein interaction with Bimolecular Fluorescence Complementation Assays (BIFCs).These parallel approaches provide a promising innovative solution in the multifaceted challenge of the overall resistance to anti-EGFR therapies. This will be achieved with the development of multimodal CNT-based nanoplatforms carrying the fluorescent conjugates of EGFR inhibitors intracellularly independenly of EGFR extracellular recognition. This system will further deliver anti-EGFR and fluorescent attributes to the nucleus. The partnership offers and a well-structured scheme of complementary skills highly inspired by the entrepreneurial spirit of academicians and research commitment of the industrial partners securing significant impact on their employability in their sector. Fields of science natural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2011-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator E.P.O.S. IASIS RESEARCH AND DEVELOPMENT LTD EU contribution € 498 425,00 Address Kosti palama 34 aspelia diam 5 1096 Lefkosia Cyprus See on map Region Κύπρος Κύπρος Κύπρος Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andreani Odysseos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON Participation ended United Kingdom EU contribution No data Address Brunswick square 29-39 WC1N 1AX London See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kostas Kostarelos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON Participation ended EU contribution No data Address Gower street WC1E 6BT London See on map Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DIMOKRITIO PANEPISTIMIO THRAKIS Greece EU contribution € 166 243,00 Address Panepistimioupoli rectorate building 691 00 Komotini See on map Region Βόρεια Ελλάδα Aνατολική Μακεδονία Ροδόπη Activity type Higher or Secondary Education Establishments Administrative Contact Bogos Agianian (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 France EU contribution € 242 441,00 Address Place jussieu 4 75252 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Ella Bouquet (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PRO-ACTINA CHIMIKI TECHNOLOGIA ANONIMI ETAIRIA Greece EU contribution € 165 414,00 Address Delfonstreet 20 15125 Marousi athens See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alexandros Strongilos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 337 882,00 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Claire Faichnie (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data