SemanticHealthNet will develop a scalable and sustainable pan-European organisational and governance process for the semantic interoperability of clinical and biomedical knowledge, to help ensure that EHR systems are optimised for patient care, public health and clinical research across healthcare systems and institutions.Through a clinically-driven workplan, exemplified in cardiovascular medicine, SemanticHealthNet will capture the needs for evidence-based, patient-centred integrated care and for public health, encapsulating existing European consensus in the management of chronic heart failure and cardiovascular prevention. Experts in EHR architectures, clinical data structures, terminologies and ontology will combine, tailor and pilot their best-of-breed resources in response to the needs articulated by clinicians and public health physicians.These exemplars will be cross-referenced with other domains and stakeholder perspectives via Clinical and Industrial Advisory Boards and interactions with other projects in Topic 5.3. The project will generalise and formalise the methods and best practices in how to combine and adapt informatics resources to support semantic interoperability, and how these can be developed and supported at scale. Health authorities, clinical professionals, ministries, vendors, purchasers, insurers are involved to ensure the project approach and results are realistically adoptable and viable, building on the SemanticHEALTH and CALLIOPE roadmaps.A business model to justify strategic investments, including the opportunity costs for key stakeholders such as SDOs, industry, will be defined. This, and links with epSOS II and the eHealth Governance Initiative, will inform the shape of the Virtual Organisation that this Network will establish to sustain semantic interoperability developments and their adoption.The consortium comprises more than 40 internationally recognised experts, including from USA and Canada, ensuring a global impact.