Obiettivo Although the rate of food contamination with Listeria monocytogenes is low, the mortality rate that is caused by this microorganism is high,and for this reason, it is placed on the top of the list of pathogens of concern for the public health and consequently for the food industry. L.monocytogenes has emerged as a food-borne pathogen the last decades, due to changes in food processing, consumer habits and thedemand for minimally processed foods. The molecular mechanism of virulence has gained a lot of attention and many steps of thiscomplex process have been elucidated to various levels. All L. monocytogenes strains found in foods should be considered to bepathogenic. However, the relative virulence of individual L. monocytogenes isolates can vary substantially. The genetic basis underlyingthese virulence differences is not yet understood. Differences in gene content exist between strains of different serovars and origins.Differences among strains could also be due to different gene expression/regulation of the core genes of the microorganism. The ability torapidly determine the pathogenic potential of L. monocytogenes strains is integral to the control and prevention campaign againstlisteriosis. Throughout the years, different approaches have been employed to assess virulence: in vivo bioassays, in vitro cell assays andtargeting virulence-associated proteins and genes. However, these methods have disadvantages such as the need for laboratory animals(bioassays) and the time constraints. Furthermore, targeting virulence genes gives only an indication of the virulence potential of strains.Nowadays, powerful alternatives such as microarrays and reverse transcriptional quantitative polymerase chain reaction (RT-qPCR) areavailable that can assist in the definition of the virulence potential of L. monocyotogenes strains by the means of modelling. Campo scientifico medical and health scienceshealth sciencespublic healthsocial sciencessociologydemographymortalitynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesmicrobiology Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2011-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore UNIVERSITA DEGLI STUDI DI TORINO Contributo UE € 50 000,00 Indirizzo VIA GIUSEPPE VERDI 8 10124 Torino Italia Mostra sulla mappa Regione Nord-Ovest Piemonte Torino Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Luca Cocolin (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato