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Content archived on 2024-06-18

Developmental Origins of Healthy and Unhealthy Ageing: The Role of Maternal Obesity

Objective

Europe has the highest proportion of elderly people in the world. Cardiovascular disease (CVD), type 2 diabetes (T2D), sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Obesity is a main health concern in the world. In the EU one-third of women of reproductive age are overweight and 20% are obese, a prevalence predicted to double in the next decade. There is growing evidence that maternal obesity increases the long term risk of CVD, T2D and neurodegenerative morbidity in the offspring. This project will clarify if and to what extent maternal obesity leads to premature and unhealthy ageing, by causing early, i.e. pre-/perinatal metabolic and genetic vulnerability, starting from insulin resistance and glucocorticoid exposure, leading to oxidative-stress, telomere/DNA damage, epigenetic changes, interacting with genetic and environmental variability, resulting in altered gene expression/repair, and ultimately in disease during life and pathological ageing. We will investigate the postulated mechanisms during pregnancy and development, their life long consequences in animal models and in large human cohorts followed from prenatal life until ageing, and the possibility to intervene when the condition is still reversible. Surrogate markers to estimate early risk and monitor progression-regression will be defined. This project will comprehensively address the expected impacts listed in the work programme HEALTH.2011.2.2.2-2 targeting the improvement of health and healthy ageing of a broad/broadening European population. The participation of a research intensive SME and European NGOs guarantees success in biomarker discovery-innovation and in dissemination-public preventive programs. The scientific excellence and complementariness of the partners and the relevance of the target health problem will make a highly significant impact on the European policy and research in this area.

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-HEALTH-2011-two-stage
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CP-FP - Small or medium-scale focused research project

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
EU contribution
€ 799 994,00
Address
PIAZZALE ALDO MORO 7
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (9)

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