Objective In vivo, cross-presentation of exogenous antigens has mostly been associated with dendritic cells. This process, which does not depend on the degradation of newly synthesized proteins, allows for the acquisition and presentation of peptides derived from exogenous antigens on MHC class I molecules. Better understanding of the mechanism of cross-presentation is essential, first because it appears crucial for priming CD8-positive T cell responses, and second because it has implications for various issues such as transplantation, viral infection, vaccination, autoimmune diseases and cancer. Recent reports have highlighted crucial aspects of the cellular mechanisms involved in cross-presentation. However, our understanding of this phenomenon remains incomplete. Here, we propose to study cross-presentation of exogenous antigens by confocal video microscopy and biochemical approaches, with a focus on the cross-presentation of tumour specific antigens of the MAGE-type. This study will be realized through a collaboration between two partners: the laboratory of Pr Cresswell in the Section of Immunobiology in Yale University Medical School, and the Cellular Genetics Unit of the Christian de Duve Institute of Cellular Pathology. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepathologymedical and health sciencesclinical medicinetransplantation Keywords cross-presentation dendritic cells Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Call for proposal FP6-2004-MOBILITY-6 See other projects for this call Funding Scheme OIF - Marie Curie actions-Outgoing International Fellowships Coordinator CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY EU contribution No data Address Avenue Hippocrate 74 UCL 7550 BRUSSELS Belgium See on map Links Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all YALE UNIVERSITY SCHOOL OF MEDICINE United States EU contribution No data Address 300 Cedar Street P.O. Box 208011 NEW HAVEN, CT See on map Links Website Opens in new window Total cost No data
