Molecular basis for chromosome cohesion in sporulating cells of Bacillus subtilis

Projektinformationen

BASIC COHESION

ID Finanzhilfevereinbarung: 22790

Startdatum 1 Juli 2006

Enddatum 31 Dezember 2007

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 168 233,00

Koordiniert durch

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom

Ziel

Efficient segregation of chromosomes is crucially important in all living organisms. In eukaryotes, cohesion of the replicated chromosomes is an important step in this process, which occurs prior to attachment to the mitotic spindle apparatus. Chromosome cohesion also occurs in some prokaryotes. In sporulating cells of Bacillus subtilis the replicated sister chromosomes adopt an unusual extended conformation, known as the axial filament, which reaches from one cell pole to the other. It is well-known that formation of the axial filament depends on anchoring of the replicated chromosomes to the cell poles. However, it also appears to involve cohesion between sister chromosomes at mid-cell. The research described in this proposal aims at unravelling the mechanism by which the two sister chromosomes are held together. Knowledge emerging from this research will deepen our understanding of chromosome segregation in B. subtilis, and more generally, will contribute to the fascinating question of how nucleoid architecture is coupled with cell division and development in this organism.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › genetics › chromosomes

Schlüsselbegriffe

• Axial filament
• Bacillus subtilis
• chromosome cohesion
• nucleoid architecture
• sporulation

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

EIF - Marie Curie actions-Intra-European Fellowships

Koordinator

UNIVERSITY OF NEWCASTLE UPON TYNE

• EU-Beitrag: Keine Daten
• Adresse: 6 Kensington Terrace ; NEWCASTLE UPON TYNE ; Vereinigtes Königreich
• Gesamtkosten: Keine Daten