Obiettivo Efficient segregation of chromosomes is crucially important in all living organisms. In eukaryotes, cohesion of the replicated chromosomes is an important step in this process, which occurs prior to attachment to the mitotic spindle apparatus. Chromosome cohesion also occurs in some prokaryotes. In sporulating cells of Bacillus subtilis the replicated sister chromosomes adopt an unusual extended conformation, known as the axial filament, which reaches from one cell pole to the other. It is well-known that formation of the axial filament depends on anchoring of the replicated chromosomes to the cell poles. However, it also appears to involve cohesion between sister chromosomes at mid-cell. The research described in this proposal aims at unravelling the mechanism by which the two sister chromosomes are held together. Knowledge emerging from this research will deepen our understanding of chromosome segregation in B. subtilis, and more generally, will contribute to the fascinating question of how nucleoid architecture is coupled with cell division and development in this organism. Campo scientifico natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesgeneticschromosomes Parole chiave Axial filament Bacillus subtilis chromosome cohesion nucleoid architecture sporulation Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Invito a presentare proposte FP6-2004-MOBILITY-5 Vedi altri progetti per questo bando Meccanismo di finanziamento EIF - Marie Curie actions-Intra-European Fellowships Coordinatore UNIVERSITY OF NEWCASTLE UPON TYNE Contributo UE Nessun dato Indirizzo 6 Kensington Terrace NEWCASTLE UPON TYNE Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
