Directed Evolution of Enzymes that Modify Histone Tails

Projektinformationen

DIREVME

ID Finanzhilfevereinbarung: 25219

Startdatum 1 Juni 2006

Enddatum 29 Februar 2008

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 168 233,00

Koordiniert durch

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Ziel

The modification of chromatin structure (e.g. by acetylation or methylation of the histone tails) plays a central role in transcriptional regulation, constituting an epigenetic code. Currently the dissection of the roles of individual modified histone residues is limited by low activity and/or specificities of isolated/recombinant histone modifying enzymes. We propose to combine directed evolution with biochemical and in vivo assays to understand the functional consequences of modifying specific histone residues. Natural histone-modifying enzymes will be used as starting points to evolve enzymes with have enhanced activities and altered specificities to probe biological function.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Schlüsselbegriffe

• compartmentalised selections
• directed evolution
• epigenetic code
• histone modification

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

EIF - Marie Curie actions-Intra-European Fellowships

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• EU-Beitrag: Keine Daten
• Adresse: The Old Schools, Trinity Lane ; CAMBRIDGE ; Vereinigtes Königreich
• Gesamtkosten: Keine Daten