Obiettivo Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialization of engineered products. Similar to other biotechnology sectors (e.g. vaccines or recombinant protein production), bioreactor systems could play a central role in establishing engineered tissues in the clinic. In fact, by automating and streamlining manufacturing processes, they would allow to improve product reproducibility, safety, standardization and possibly reach cost-effectiveness. This project aims at the development, pre-clinical and clinical testing of a sensor-based bioreactor system for the production of functional, autologous engineered grafts with reproducible properties. The bioreactor-based manufacturing paradigm will be addressed in the specific context of cartilage repair. Innovative features of the proposed tissue engineering strategy will include: (i) an automated and controlled production system, (ii) bioreactor conforming to regulatory guidelines, (iii) simplified, streamlined, and scalable tissue engineering process, (iv) on-line monitoring of culture/quality parameters, and (v) data management systems for traceability. To achieve these goals, BIO-COMET brings together internationally renowned leaders in the field of regenerative medicine, from academic, clinical and industrial research institutions. Successful implementation of the project will be instrumental to extend use of bioreactor-based platforms beyond cartilage tissue engineering, with the ultimate goal to facilitate broad utilization and commercialization of cell-based grafts as therapeutic solutions. Campo scientifico engineering and technologymechanical engineeringmanufacturing engineeringengineering and technologyenvironmental biotechnologybioremediationbioreactorsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2011.1.4-2 - Tools, technologies and devices for application in regenerative medicine Invito a presentare proposte FP7-HEALTH-2011-two-stage Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore UNIVERSITATSSPITAL BASEL Contributo UE € 1 269 000,00 Indirizzo HEBELSTRASSE 32 4031 Basel Svizzera Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contatto amministrativo Ivan Martin (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF BRISTOL Regno Unito Contributo UE € 559 892,60 Indirizzo BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Mostra sulla mappa Regione South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Maria Davies (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato SVEUCILISTE U ZAGREBU Croazia Contributo UE € 614 729,60 Indirizzo TRG REPUBLIKE HRVATSKE 14 10000 Zagreb Mostra sulla mappa Regione Hrvatska Grad Zagreb Grad Zagreb Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Hrvoje Matakovic (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ISTITUTO ORTOPEDICO RIZZOLI Italia Contributo UE € 620 500,00 Indirizzo VIA DI BARBIANO 1/10 40136 Bologna Mostra sulla mappa Regione Nord-Est Emilia-Romagna Bologna Tipo di attività Research Organisations Contatto amministrativo Andrea Rizzi (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CELLEC BIOTEK AG Svizzera Contributo UE € 885 000,00 Indirizzo VOGESENSTRASSE 135 4056 BASEL Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Montefiori Michele (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato PRESENS PRECISION SENSING GMBH Germania Contributo UE € 568 200,00 Indirizzo AM BIOPARK 11 93053 Regensburg Mostra sulla mappa Regione Bayern Oberpfalz Regensburg, Kreisfreie Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Christian Krause (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato HOLOSTEM TERAPIE AVANZATE SRL Italia Contributo UE € 429 500,40 Indirizzo VIA GLAUCO GOTTARDI 100 41125 Modena Mostra sulla mappa Regione Nord-Est Emilia-Romagna Modena Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Graziella Pellegrini (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato OCTANE BIOTECH INC Canada Contributo UE € 641 268,00 Indirizzo CATARAQUI WOODS DRIVE 640 K7P 2Y5 KINGSTON Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Timothy Smith (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato FIN-CERAMICA FAENZA SPA Italia Contributo UE € 406 276,50 Indirizzo Via Granarolo 177/3 48018 Faenza Mostra sulla mappa Regione Nord-Est Emilia-Romagna Ravenna Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Elisa Figallo (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato