Objective
The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.
Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so its social and economic burden will grow with the ageing of the European population. Current treatment options for the 80 to 85% of all strokes due to cerebral ischaemia - around. 900,000 events in Europe every year, or one every 40 seconds - are extremely limited.
Systematic review of experimental studies suggests that hypothermia is the most promising intervention identified to date. Therapeutic cooling is effective in reducing ischaemic brain injury following cardiac arrest, and hypothermia is therefore considered by experts the most promising treatment for patients with acute ischaemic stroke, next to reperfusion strategies.
The EuroHYP-1 trial is a pan-European, open, randomised, phase III clinical trial which will assess the benefit or harm of therapeutic cooling in 800 awake adult patients with acute ischaemic stroke. In addition to efficacy and safety, the economic impact of therapeutic hypothermia will be assessed, along with several sub-studies involving imaging, ultrasound, and biomarker methods.
The investigators involved in the EuroHYP-1 consortium are leading European experts in statistical design and analysis, therapeutic hypothermia, imaging, health economics, ultrasound, biomarkers, and trial execution (implementation and monitoring). Moreover – in addition to these academic experts the consortium also involves European patient and family advocacy groups and small and medium-sized enterprises, and the joint endeavours of this extended team will ensure the successful enrolment of patients at fifty hospitals across 15 countries in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology stroke
- social sciences economics and business economics health economics
- natural sciences physical sciences acoustics ultrasound
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2011-two-stage
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91054 ERLANGEN
Germany
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Participants (39)
Participation ended
69120 HEIDELBERG
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3400 Hillerod
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EH8 9YL Edinburgh
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1050 Bruxelles / Brussel
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10117 Berlin
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3584 CX Utrecht
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1000 BRUXELLES
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04109 Leipzig
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00185 Roma
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G12 8QQ Glasgow
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291 89 Kristianstad
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02 957 Warszawa
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75654 PARIS
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NG7 2RD Nottingham
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08007 Barcelona
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08035 BARCELONA
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01069 DRESDEN
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94010 Creteil
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20156 MILANO
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20520 Turku
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59037 Lille
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8000 Brugge
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80333 Muenchen
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22370 LUND
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1040 WIEN
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31029 VITTORIO VENETO TV
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KT113EP Cobham
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BT29 4QY Crumlin
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08173 SANT CUGAT DEL VALLES
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3084 HEIDELBERG
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06800 Cankaya Ankara
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691 00 KOMOTINI
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LT-08406 VILNIUS
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51005 TARTU
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6020 INNSBRUCK
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75015 PARIS
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75014 Paris
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602 00 Brno
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8 DUBLIN
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