Objective
The goal of this project is to perform a European phase II clinical trial to demonstrate that PDGF-BB acts as a unique regenerative therapy for Parkinson’s Disease (PD), aimed at reversing the course of the disease, by promotion of endogenous brain repair mechanisms. Current pharmacological therapies for PD carry side-effects and become less effective as the disease progresses. This causes immense suffering for patients in their daily lives. There is currently no established disease-modifying, regenerative or neuroprotective treatment for PD. Such a therapy would revolutionize the capacity to effectively treat PD patients and could dramatically reduce the multi-billion € annual cost to Europe. The project will conduct a multi-centre clinical trial in PD using intracerebroventricular administration of PDGF-BB. To obtain the most relevant information from the clinical trial, state-of-the-art disease rating scales and brain imaging technology will be used to monitor changes related to restoration of brain function. Planning and conduct of the clinical study will involve investigators and advisors with extensive expertise in the disease-area and experience with participating in clinical studies. To further advance the understanding of the regenerative mechanism, preclinical studies will be performed. We will set up a framework of partners to ensure proper governance of the clinical study, compliant with fundamental ethical principles of European regulations concerning studies on “advanced therapies medicinal products”. PD patient associations and experts in ethics will assist the project with patient information and recruitment strategies. Internal training sessions, external meetings and dissemination of results will be coordinated by a communication expert firm. A robust and realistic commercialization strategy including IP, health economy and reimbursement will be developed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology governance
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- humanities philosophy, ethics and religion ethics ethical principles
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2011-two-stage
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
114 33 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.