Objective
Global increases in lifespan make the challenge to prevent and treat Alzheimer’s disease (AD) urgent. While the etiology of non-familial/sporadic AD is largely unknown, many AD patients have elevated stress hormone (glucocorticoid, GC) levels and recent animal studies show that high GC levels promote production of amyloidogenic peptides (key pathogenic players in AD) in association with memory deficits. Stress/GC are implicated in mood and cognitive disorders, and meta-analyses identify depression (often associated with cognitive deficits) as a risk for AD. This, and the fact that depression and AD involve similar limbic-cortical substrates, suggests shared spatio-temporal trajectories, with the two conditions representing early and late manifestations of increased amyloid beta (A-beta) levels. This proposal aims to i) define the spatio-temporal progression of the impact of stress on A-beta production based on morphochemical (immunochemical, gene expression, morphometric) mapping; and ii) identify the cellular targets and molecular mechanisms through which stress is pro-amyloidogenic (multiplex qPCR, Western blot, enzymatic activity assay). Two transgenic mice (arcAbeta and RiboTag mice) of different ages and sexes (women are more prone to AD and depression) will be used. Analysis of cellular events in genetically-marked (RiboTag) neuronal sub-populations adds innovative value. The applicant will apply his existing skills in structural and behavioral neurobiology, complemented by additional (primary neuronal culture, molecular and cellular neuroanatomy) and state-of-the-art methodologies (high-speed voltage-sensitive dye imaging and optogenetics), acquired at the host institute. Besides offering technical and generic skills, the host institute allows dialogue between basic and clinical researchers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.