EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations

Project Information

EPIC-CVD

Grant agreement ID: 279233

Project closed

Start date 1 January 2012

End date 31 December 2015

Funded under

• Specific Programme "Cooperation": Health

Total cost € 7 947 602,67

EU contribution € 5 987 266,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Objective

"EPIC-CVD's overarching goal is to provide clinicians and policy-makers with a menu of evidence-based options for cost-effective individualised risk assessment that enables the EU's increasingly resource-constrained economies to achieve more personalised predictive medicine in harmony with Europe's diverse cultures and healthcare systems.

We will achieve this through developing and validating innovative risk scores and efficient screening strategies by studying 75 high priority soluble biomarkers and 215,000 carefully selected genetic variants in the most powerful population-based prospective study ever conducted of incident coronary heart disease, stroke, and type 2 diabetes across 10 diverse European countries. EPIC-CVD will provide the first consideration across Europe of risk scores with information on the interplay of nature and nurture together with biomarkers of lifestyle, biological pathways, vascular injury, and ageing.

Our multidisciplinary consortium involves world-leading expertise in population health science, laboratory science (including VITAS, an SME partner, renowned for nutritional biomarker assays), translational science, and implementation science. This rare combination of expertise will enable systematic consideration of the implications of risk scores and screening strategies for predictive accuracy, feasibility, safety, acceptability, and cost-effectiveness. The impact on clinical decision making and clinical outcomes will be demonstrated in a new randomised trial of risk scores in relation to ""patient-centred"" outcomes that assess attitudes, behaviours, and biological risk factors.

Key stakeholders (eg, healthcare professionals, regulators, industry) will be closely engaged by the project. Policy recommendations mindful of the broader societal implications of targeted screening will be tailored to Europe's diverse needs and systematically disseminated to various audiences. This initiative will derive major synergy from related efforts."

Fields of science

• medical and health sciences › health sciences
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › neurology › stroke

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH.2011.2.4.2-2 - Evaluation and validation studies of clinically useful biomarkers in prevention and management of cardiovascular diseases

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

• EU contribution: € 2 582 778,45
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge ; United Kingdom
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: John Danesh (Prof.)
• Total cost: No data

Participants (29)

VITAS AS

Norway

• EU contribution: € 1 073 697,90
• Address: GAUSTADALLEEN 21 ; 0349 Oslo
• Region: Norge › Oslo og Viken › Oslo
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Thomas Gundersen (Dr.)
• Total cost: No data

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

• EU contribution: € 206 684,40
• Address: HEIDELBERGLAAN 100 ; 3584 CX Utrecht
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Yvonne Van Der Schouw (Prof.)
• Total cost: No data

LUNDS UNIVERSITET

Sweden

• EU contribution: € 59 314,80
• Address: Paradisgatan 5c ; 22100 Lund
• Region: Södra Sverige › Sydsverige › Skåne län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Olle Melander (Prof.)
• Total cost: No data

MEDICAL RESEARCH COUNCIL

United Kingdom

• EU contribution: € 411 174,30
• Address: 20 Park Crescent ; W1B 1AL LONDON
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Nick Wareham (Prof.)
• Total cost: No data

CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER

France

• EU contribution: € 159 500,40
• Address: 25 AVENUE TONY GARNIER ; 69007 Lyon 7eme
• Region: Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône
• Activity type: Research Organisations
• Administrative Contact: Maimuna Mendy (Dr.)
• Total cost: No data

IIGM FOUNDATION

Italy

• EU contribution: € 23 644,80
• Address: PIAZZA BERNINI 5 ; 10138 Torino
• Region: Nord-Ovest › Piemonte › Torino
• Activity type: Research Organisations
• Administrative Contact: Giuseppe Matullo (Prof.)
• Total cost: No data

DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE

Germany

• EU contribution: € 23 544,00
• Address: Arthur-Scheunert-Allee 114-116 ; 14558 Nuthetal
• Region: Brandenburg › Brandenburg › Potsdam-Mittelmark
• Activity type: Research Organisations
• Administrative Contact: Heiner Boeing (Prof.)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

• EU contribution: € 196 416,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Palalic Tatjana (Ms.)
• Total cost: No data

HELLENIC HEALTH FOUNDATION

Greece

• EU contribution: € 27 258,00
• Address: KAISAREIAS 13 & ALEXANDROUPOLEOS ; 11527 Athens
• Region: Αττική › Aττική › Κεντρικός Τομέας Αθηνών
• Activity type: Research Organisations
• Administrative Contact: Antonia Trichopoulou (Prof.)
• Total cost: No data

ESCUELA ANDALUZA DE SALUD PUBLICA SA

Spain

• EU contribution: € 145 689,75
• Address: CUESTA DEL OBSERVATORIO CAMPUS UNIVERSITARIO DE CARTUJA 4 ; 18011 Granada
• Region: Sur › Andalucía › Granada
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Sánchez-Pérez María-José (Dr.)
• Total cost: No data

AARHUS UNIVERSITET

Denmark

• EU contribution: € 51 057,20
• Address: NORDRE RINGGADE 1 ; 8000 Aarhus C
• Region: Danmark › Midtjylland › Østjylland
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Dorthe Hejl Boye (Ms.)
• Total cost: No data

UMEA UNIVERSITET

Sweden

• EU contribution: € 18 511,20
• Address: UNIVERSITETOMRADET ; 901 87 Umea
• Region: Norra Sverige › Övre Norrland › Västerbottens län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Goran Hallmans (Prof.)
• Total cost: No data

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

• EU contribution: € 9 585,00
• Address: Antonie Van Leeuwenhoeklaan 9 ; 3721 MA Bilthoven
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Research Organisations
• Administrative Contact: Jolanda Maria Antoinette Boer (Dr.)
• Total cost: No data

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

• EU contribution: € 10 520,40
• Address: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tim Key (Prof.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

• EU contribution: € 8 194,80
• Address: CORSO UMBERTO I, 40 ; 80138 Napoli
• Region: Sud › Campania › Napoli
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Salvatore Panico (Dr.)
• Total cost: No data

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

• EU contribution: € 8 421,00
• Address: IM NEUENHEIMER FELD 280 ; 69120 Heidelberg
• Region: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Activity type: Research Organisations
• Administrative Contact: Ina Krischek (Dr.)
• Total cost: No data

FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI

Italy

• EU contribution: € 9 111,60
• Address: Via Venezian 1 ; 20133 Milan
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Research Organisations
• Administrative Contact: Vittorio Krogh (Dr.)
• Total cost: No data

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET

Norway

• EU contribution: € 8 173,20
• Address: HANSINE HANSENS VEG 14 ; 9019 Tromso
• Region: Norge › Nord-Norge › Troms og Finnmark
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eiliv Lund (Prof.)
• Total cost: No data

ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOGIPUZKOA

Spain

• EU contribution: € 8 898,00
• Address: PASEO DR BEGUIRISTAIN SN ; 20014 DONOSTIA-SAN SEBASTIAN
• Region: Noreste › País Vasco › Gipuzkoa
• Activity type: Research Organisations
• Administrative Contact: Irune Vegas (Ms.)
• Total cost: No data

FUNDACION PUBLICA MIGUEL SERVET

Participation ended

Spain

• EU contribution: No data
• Address: CALLE IRUNLARREA 3 CENTRO INVESTIGACION BIOMEDICA RECINTO COMPLEJO HOSPITALARIO DE NAVARRA ; 31008 Pamplona
• Region: Noreste › Comunidad Foral de Navarra › Navarra
• Activity type: Research Organisations
• Administrative Contact: Conchi Moreno-Iribas (Dr.)
• Total cost: No data

FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA

Spain

• EU contribution: € 10 222,80
• Address: CALLE CAMPO 12 PABELLON DOCENTE DEL HOSPITAL CLINICO UNIVERSITARIO VIRGEN DE LA ARRIXACA 3 PLANTA EL PALMA ; 30120 Murcia
• Region: Sur › Región de Murcia › Murcia
• Activity type: Research Organisations
• Administrative Contact: Carmen Navarro (Dr.)
• Total cost: No data

ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA

Italy

• EU contribution: € 8 792,10
• Address: VIA COSIMO IL VECCHIO 2 ; 50139 Firenze
• Region: Centro (IT) › Toscana › Firenze
• Activity type: Other
• Administrative Contact: Domenico Palli (Dr.)
• Total cost: No data

CONSEJERIA DE SALUD - PRINCIPADO DE ASTURIAS

Spain

• EU contribution: € 10 020,50
• Address: Ciriaco Miguel Vigil 9 ; 33006 Oviedo
• Region: Noroeste › Principado de Asturias › Asturias
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Laudina Rodriguez (Dr.)
• Total cost: No data

THE UNIVERSITY OF AUCKLAND

New Zealand

• EU contribution: No data
• Address: PRINCES STREET 24 ; 1010 Auckland
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kate Harrower
• Total cost: No data

RAND EUROPE COMMUNITY INTEREST COMPANY

United Kingdom

• EU contribution: € 74 750,00
• Address: EASTBROOK SHAFTESBURY ROAD ; CB2 8BF CAMBRIDGE CAMBRIDGESHIRE
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: Ellen Nolte (Dr.)
• Total cost: No data

FOUNDATION FOR GENOMICS & POPULATION HEALTH

United Kingdom

• EU contribution: € 47 276,40
• Address: WORTS CAUSEWAY 2 ; CB1 8RN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: Hilary Burton (Dr.)
• Total cost: No data

ASSOCIAZIONE IBLEA PER LA RICERCA EPIDEMIOLOGICA ONLUS

Italy

• EU contribution: € 8 387,00
• Address: PIAZZA ANCIONE 2 ; 97100 RAGUSA
• Activity type: Research Organisations
• Administrative Contact: Francesco Occhipinti (Dr.)
• Total cost: No data

ORGANISMO AUTONOMO INSTITUTO DE SALUD PUBLICA Y LABORAL DE NAVARRA

Spain

• EU contribution: € 8 642,00
• Address: CL LEYRE 15 ; 31003 Pamplona
• Region: Noreste › Comunidad Foral de Navarra › Navarra
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Marisol Fragoso (Ms.)
• Total cost: No data

NIGHTINGALE HEALTH OYJ

Finland

• EU contribution: € 777 000,00
• Address: MANNERHEIMINTIE 164A ; 00300 Helsinki
• Region: Manner-Suomi › Helsinki-Uusimaa › Helsinki-Uusimaa
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Suna Teemu (Mr.)
• Total cost: No data