Objective
"EPIC-CVD's overarching goal is to provide clinicians and policy-makers with a menu of evidence-based options for cost-effective individualised risk assessment that enables the EU's increasingly resource-constrained economies to achieve more personalised predictive medicine in harmony with Europe's diverse cultures and healthcare systems.
We will achieve this through developing and validating innovative risk scores and efficient screening strategies by studying 75 high priority soluble biomarkers and 215,000 carefully selected genetic variants in the most powerful population-based prospective study ever conducted of incident coronary heart disease, stroke, and type 2 diabetes across 10 diverse European countries. EPIC-CVD will provide the first consideration across Europe of risk scores with information on the interplay of nature and nurture together with biomarkers of lifestyle, biological pathways, vascular injury, and ageing.
Our multidisciplinary consortium involves world-leading expertise in population health science, laboratory science (including VITAS, an SME partner, renowned for nutritional biomarker assays), translational science, and implementation science. This rare combination of expertise will enable systematic consideration of the implications of risk scores and screening strategies for predictive accuracy, feasibility, safety, acceptability, and cost-effectiveness. The impact on clinical decision making and clinical outcomes will be demonstrated in a new randomised trial of risk scores in relation to ""patient-centred"" outcomes that assess attitudes, behaviours, and biological risk factors.
Key stakeholders (eg, healthcare professionals, regulators, industry) will be closely engaged by the project. Policy recommendations mindful of the broader societal implications of targeted screening will be tailored to Europe's diverse needs and systematically disseminated to various audiences. This initiative will derive major synergy from related efforts."
Fields of science
Call for proposal
FP7-HEALTH-2011-two-stage
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Funding Scheme
CP-FP - Small or medium-scale focused research projectCoordinator
CB2 1TN Cambridge
United Kingdom
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Participants (29)
0349 Oslo
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3584 CX Utrecht
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22100 Lund
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W1B 1AL LONDON
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69007 Lyon 7eme
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10138 Torino
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14558 Nuthetal
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SW7 2AZ LONDON
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11527 Athens
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18011 Granada
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8000 Aarhus C
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901 87 Umea
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3721 MA Bilthoven
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OX1 2JD Oxford
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80138 Napoli
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69120 Heidelberg
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20133 Milan
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9019 Tromso
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20014 DONOSTIA-SAN SEBASTIAN
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Participation ended
31008 Pamplona
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30120 Murcia
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50139 Firenze
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33006 Oviedo
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1010 Auckland
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CB2 8BF CAMBRIDGE CAMBRIDGESHIRE
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CB1 8RN Cambridge
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97100 RAGUSA
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31003 Pamplona
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00300 Helsinki
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