Objective
Infertility is a major problem that affects domestic mammals and declining fertility represents an obstacle in maintaining profitability of dairy farms in Europe and worldwide. Since declining fertility of cattle is mainly due to the poor quality of the oocytes, defining the factors and mechanisms that affect oocyte quality, is essential for improving female fertility. In particular, basic knowledge of which proteins within the oocyte regulate meiosis, oocyte fertilizability and early embryonic development would be advantageous. Based on our preliminary data, we propose that Progesterone Receptor Membrane Component 1 (PGRMC1) is one of the key factors that regulate mammalian oocyte quality. This hypothesis will be rigorously tested by determining 1) whether PGRMC1 plays an essential role in maintaining the ability of bovine oocytes to complete meiosis, undergo fertilization and develop to an healthy embryo in vitro, by genetically manipulating the levels of PGRMC1 within the oocyte, and 2) PGRMC1’s mechanism of action by identifying its interacting proteins within the oocyte.
The scientific program is directly linked to the studies that the candidate has conducted during her period of mobility at the University of Connecticut Health Center (USA) and should result in important discoveries in the field of reproductive biology. If granted, this study will contribute to the improvement of the quality of European research and will improve significantly the lifelong training and career development of the applicant, providing the opportunity to capitalize in Italy on her experience on this promising topic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences developmental biology
- social sciences sociology demography fertility
- natural sciences biological sciences genetics heredity
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences reproductive biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
20122 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.