Objetivo Infertility is a major problem that affects domestic mammals and declining fertility represents an obstacle in maintaining profitability of dairy farms in Europe and worldwide. Since declining fertility of cattle is mainly due to the poor quality of the oocytes, defining the factors and mechanisms that affect oocyte quality, is essential for improving female fertility. In particular, basic knowledge of which proteins within the oocyte regulate meiosis, oocyte fertilizability and early embryonic development would be advantageous. Based on our preliminary data, we propose that Progesterone Receptor Membrane Component 1 (PGRMC1) is one of the key factors that regulate mammalian oocyte quality. This hypothesis will be rigorously tested by determining 1) whether PGRMC1 plays an essential role in maintaining the ability of bovine oocytes to complete meiosis, undergo fertilization and develop to an healthy embryo in vitro, by genetically manipulating the levels of PGRMC1 within the oocyte, and 2) PGRMC1’s mechanism of action by identifying its interacting proteins within the oocyte.The scientific program is directly linked to the studies that the candidate has conducted during her period of mobility at the University of Connecticut Health Center (USA) and should result in important discoveries in the field of reproductive biology. If granted, this study will contribute to the improvement of the quality of European research and will improve significantly the lifelong training and career development of the applicant, providing the opportunity to capitalize in Italy on her experience on this promising topic. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinssocial sciencessociologydemographyfertilitynatural sciencesbiological sciencesgeneticshereditymedical and health sciencesclinical medicineembryologynatural sciencesbiological sciencesreproductive biology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Convocatoria de propuestas FP7-PEOPLE-2011-CIG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-CIG - Support for training and career development of researcher (CIG) Coordinador UNIVERSITA DEGLI STUDI DI MILANO Aportación de la UE € 100 000,00 Dirección Via Festa Del Perdono 7 20122 Milano Italia Ver en el mapa Región Nord-Ovest Lombardia Milano Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Sabina Sangalli (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
