Objective
Alzheimer’s disease is the most common form of dementia which seriously interferes with the daily life of millions of people. People suffering from Alzheimer’s disease show the accumulation of two misfolded proteins in the nerve cells of their brains – amyloid plaques and tau tangles. Although many aspects of the Alzheimer’s disease pattern are well-established, only little is known about the onset, development and progression of this disease. Thus, early detection, including diagnosis before symptoms become visible, is still not possible yet. Furthermore, the development of drugs designed to slow down or even prevent Alzheimer’s disease progression is very difficult and tedious.
In the envisaged project, a microorganism, the filamentous fungus Aspergillus niger, will be used to study the onset and development of Alzheimer’s disease. The presence of misfolded proteins in this microorganism provokes a cellular reaction that shows many parallels to what is known from nerve cells. It seems that both man and fungus use similar defense strategies to detect and get rid of dangerous misfolded proteins. This makes A. niger very appealing for use as a model system to explore in utmost detail the origin and temporal progression of Alzheimer’s disease. As it is a fast-growing and easy genetically tractable organism, respective analyses can be performed very cost and time effective, something which is not feasible when working with human cell models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences microbiology mycology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
10623 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.