Cel A fundamental question in biology is to understand the mechanisms underlying cell plasticity. Such plasticity or potency is essential to form multiple cell types upon differentiation. In mammals, upon fertilization and fusion of the gametes –two highly differentiated cells- intense chromatin remodeling and epigenetic reprogramming, the reversion into an undifferentiated state, are essential to restore full developmental potency (totipotency). Subsequent development and differentiation are accompanied with progressive loss of plasticity. The transition between totipotency and the gradual loss of plasticity is thought to be regulated by yet-unknown epigenetic mechanisms.The embryonic chromatin displays unique features compared to differentiated cells, including the lack of ‘conventional’ heterochromatin. We hypothesise that the transition from a totipotent state to a differentiated one is regulated by changes in chromatin states, particularly by de novo acquisition of heterochromatin domains.This project is designed to reveal the nuclear foundations of totipotency by determining the molecular mechanisms underlying the establishment of heterochromatin and their functional role in maintaining totipotency using the mouse embryo as model.We will do this by:i)determining the functional relationship of heterochromatin and nuclear architectureii)by determining the effects of artificially inducing heterochromatin on cell potency during development andiii)by determining the mechanisms that regulate heterochromatin formation in the embryo.We anticipate that our studies will unravel fundamental mechanims on how chromatin states regulate cell potency during reprogramming. By uncovering such mechanisms, we expect to reveal new insights that will be useful to induce epigenetic reprogramming of differentiated cells. Our results will therefore lead to key contributions in the fields of stem cell, developmental biology, human reproduction, chromatin biology and epigenetics. Dziedzina nauki natural sciencesbiological sciencesdevelopmental biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological scienceszoologymammalogymedical and health sciencesclinical medicineembryologynatural sciencesbiological sciencesgeneticsepigenetics Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS3 - ERC Starting Grant - Cellular and Developmental Biology Zaproszenie do składania wniosków ERC-2011-StG_20101109 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Wkład UE € 542 185,62 Adres INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Niemcy Zobacz na mapie Region Bayern Oberbayern München, Landkreis Rodzaj działalności Research Organisations Kontakt administracyjny Jürgen Ertel (Dr.) Kierownik naukowy Maria-Elena Torres-Padilla (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Niemcy Wkład UE € 542 185,62 Adres INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Zobacz na mapie Region Bayern Oberbayern München, Landkreis Rodzaj działalności Research Organisations Kontakt administracyjny Jürgen Ertel (Dr.) Kierownik naukowy Maria-Elena Torres-Padilla (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Zakończenie uczestnictwa Francja Wkład UE € 953 814,38 Adres Rue Laurent Fries 1 67404 Illkirch Graffenstaden Zobacz na mapie Region Grand Est Alsace Bas-Rhin Rodzaj działalności Research Organisations Kontakt administracyjny Steve Brooks (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
