Modular beads for regeneration of bio-cofactors in enzyme-catalysed synthesis

Projektinformationen

HydRegen

ID Finanzhilfevereinbarung: 297503

Projekt abgeschlossen

Startdatum 1 Februar 2012

Enddatum 31 Januar 2013

Finanziert unter

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 163 260,40

EU-Beitrag € 148 282,00

Koordiniert durch

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Ziel

There is increasing interest in exploiting enzymes to carry out steps in industrial catalysis. Biocatalysts permit reactions to be carried out under mild conditions and with the exquisite chiral and regio-selectivity demanded of pharmaceutical, food and fine chemical products. A growing number of enzymes are already utilised across these industries. However, the repertoire of enzymes available for industrial redox transformations is greatly limited by the requirement of many oxidoreductase enzymes for supply of the hydride-carrying nicotinamide adenine dinucleotide (NAD) cofactors at stoichiometric levels. The high cost of these cofactors means that a regeneration system is essential. In this project, we develop towards commercial application, a convenient, cheap, modular regeneration system for the nicotinamide cofactors NAD+/NADH and NADP+/NADPH. Our innovation is likely to have broad applications in facilitating enzyme-catalysed steps in the preparation of pharmaceuticals and other fine chemicals, and to offer substantial advantages over currently available cofactor recycling systems. This project builds on ideas and early-stage results that have arisen rapidly out of an ERC Starting Grant-funded project. We now apply for funds to protect our Intellectual Property, explore the surrounding market and patent landscape, and develop our innovation into a robust demonstration.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs
• natural sciences › chemical sciences › catalysis › biocatalysis
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programm/Programme

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• ERC-OA-2011-PoC - European Research Council ERC Proof of Concept

Aufforderung zur Vorschlagseinreichung

ERC-2011-PoC
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CSA-SA(POC) - Supporting action (Proof of Concept)

Gastgebende Einrichtung

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Kontakt Verwaltung

Linda Pialek (Ms.)

• EU-Beitrag: € 73 946,00
• Adresse: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford ; Vereinigtes Königreich
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

Begünstigte (2)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Vereinigtes Königreich

Kontakt Verwaltung

Linda Pialek (Ms.)

• EU-Beitrag: € 73 946,00
• Adresse: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

HUMBOLDT-UNIVERSITAET ZU BERLIN

Deutschland

Kontakt Verwaltung

Renate Ubachs (Ms.)

• EU-Beitrag: € 74 336,00
• Adresse: UNTER DEN LINDEN 6 ; 10117 Berlin
• Region: Berlin › Berlin › Berlin
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten