Cel There is increasing interest in exploiting enzymes to carry out steps in industrial catalysis. Biocatalysts permit reactions to be carried out under mild conditions and with the exquisite chiral and regio-selectivity demanded of pharmaceutical, food and fine chemical products. A growing number of enzymes are already utilised across these industries. However, the repertoire of enzymes available for industrial redox transformations is greatly limited by the requirement of many oxidoreductase enzymes for supply of the hydride-carrying nicotinamide adenine dinucleotide (NAD) cofactors at stoichiometric levels. The high cost of these cofactors means that a regeneration system is essential. In this project, we develop towards commercial application, a convenient, cheap, modular regeneration system for the nicotinamide cofactors NAD+/NADH and NADP+/NADPH. Our innovation is likely to have broad applications in facilitating enzyme-catalysed steps in the preparation of pharmaceuticals and other fine chemicals, and to offer substantial advantages over currently available cofactor recycling systems. This project builds on ideas and early-stage results that have arisen rapidly out of an ERC Starting Grant-funded project. We now apply for funds to protect our Intellectual Property, explore the surrounding market and patent landscape, and develop our innovation into a robust demonstration. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-OA-2011-PoC - European Research Council ERC Proof of Concept Zaproszenie do składania wniosków ERC-2011-PoC Zobacz inne projekty w ramach tego zaproszenia System finansowania CSA-SA(POC) - Supporting action (Proof of Concept) Instytucja przyjmująca THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Wkład UE € 73 946,00 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zjednoczone Królestwo Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Linda Pialek (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Zjednoczone Królestwo Wkład UE € 73 946,00 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Linda Pialek (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych HUMBOLDT-UNIVERSITAET ZU BERLIN Niemcy Wkład UE € 74 336,00 Adres UNTER DEN LINDEN 6 10117 Berlin Zobacz na mapie Region Berlin Berlin Berlin Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Renate Ubachs (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
