Objective
Essential cellular functions rely on complex networks that coordinate highly dynamic and integrated processes. Paradoxically, our detailed knowledge of their molecular mechanisms has made it difficult to fully appreciate the core concepts involved. Therefore, the fundamental design and dynamic principles of central cellular circuits and the mechanisms that exist to buffer molecular variability and promote phenotypic homogeneity remain poorly explored. We will use the fission yeast cell cycle control as a model essential eukaryotic network to address these challenging questions. Using a synthetic strategy, we recently started exploring the minimal architecture of the mitotic cycle and demonstrated the surprising capacity of fission yeast cells to adopt simpler rewired cell cycle engines. We propose to build on these findings and address two fundamental issues. First, we will generate a series of tunable synthetic cell cycle circuits, based on our original minimal module, that further simplify cell cycle control. These rewired strains will be used to assess the design principles and dynamic components that allow for an effective and robust progression through the major cell cycle transitions. Second, we will investigate how molecular variability inherent to cellular networks can be buffered to promote population homogeneity and our minimal cell cycle systems will allow us to concentrate on the core mechanisms involved. Our studies combining synthetic approaches, genetics, single-cell manipulation in microfluidic chambers and mathematical modeling will provide novel insights into essential aspects of this central process, revealing more general concepts underlying the design of complex eukaryotic networks.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- engineering and technology electrical engineering, electronic engineering, information engineering information engineering telecommunications telecommunications networks mobile network
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.