Objective The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs.The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response.The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model.iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury. Fields of science medical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologymaterials engineeringcoating and filmsengineering and technologynanotechnologynano-materialsengineering and technologynanotechnologynanoelectronics Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2011.1.4-4 - Nanotechnology based implantable and interfaceable devices Call for proposal FP7-NMP-2011-SMALL-5 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA EU contribution € 180 885,74 Address Via universita 4 41121 Modena Italy See on map Region Nord-Est Emilia-Romagna Modena Activity type Higher or Secondary Education Establishments Administrative Contact Daniela Quaglino (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 586 685,45 Address Piazzale aldo moro 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Giuseppina Padeletti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 469 894,80 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SCRIBA NANOTECNOLOGIE SRL Italy EU contribution € 445 937,00 Address Via di corticella 183/8 40128 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrizia Alessandra Fulle (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Linköping University Sweden EU contribution € 372 595,20 Address Campus valla 581 83 Linköping See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sophie Lindesvik (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 372 996,00 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Eusebio Jimenez Arroyo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDADE DO ALGARVE Portugal EU contribution € 210 712,00 Address Campus de penha 8005 139 Faro See on map Region Continente Algarve Algarve Activity type Higher or Secondary Education Establishments Administrative Contact Henrique Leonel Gomes (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 382 904,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Gilles Pulvermuller (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Italy EU contribution € 363 180,00 Address Via zamboni 33 40126 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Higher or Secondary Education Establishments Administrative Contact Francesco Zerbetto (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data POLYGANICS INNOVATIONS BV Participation ended Netherlands EU contribution € 20 790,81 Address Rozenburglaan 15 a 9727 DL Groningen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Robbert De Graaf (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STMICROELECTRONICS SRL Participation ended Italy EU contribution € 116 695,00 Address Via c.olivetti 2 20864 Agrate brianza See on map Region Nord-Ovest Lombardia Monza e della Brianza Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Maria Grazia Podesta' (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AMIRES SARL Switzerland EU contribution € 130 300,00 Address Rue de la serre 4 2000 Neuchatel See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rudolf Frycek (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONTIPRO BIOTECH SRO Czechia EU contribution € 180 760,00 Address Dolni dobrouc 401 56102 Dolni dobrouc See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vladimir Velebny (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data