Objective
"Cisplatin is a platinum-based complex used widely as a chemotherapeutic drug. However, due to its limitations, including narrow activity range and severe side effects, other transition metal complexes are investigated as antitumorur agents. Titanium complexes that previously reached clinical trials showed fair activity, and were mainly limited by rapid decomposition in water, within minutes. Titanium complexes of diamino bis(phenolato) (""salan"") ligands studied in our laboratory under the ERC grant demonstrate extremely high stability for up to weeks in water solutions. Importantly, they have shown great potency as anti-tumour agents towards a number of cells in vitro. Their activity exceeds that of cisplatin by up to two orders of magnitude. In particular, halogenated compounds at specific positions demonstrate a combination of exceptional hydrolytic stability and particularly high cytotoxicity, and are covered in a patent application. In addition, minor effect on regular cells was observed. As the titanium has been previously shown based on in vivo testing to be significantly less toxic than platinum, (and is commonly found in food and cosmetics), several pharmaceutical companies expressed interest in our compounds. However, in vivo activity and some mechanistic insights (required for FDA approval) are fundamental for allowing commercialization. Therefore, we propose to conduct a series of experiments that will bring this research to a more ""mature"" level suitable to be undertaken by pharmaceutical companies. These include in vivo testing on mice to establish safety and activity towards different cells and by different administration techniques, including IV. Additionally, as solubility is an issue, different formulations will be assessed. Basic mechanistic studies will include evaluating potential interaction with DNA. All these studies are not covered by the ERC grant, and will be conducted in collaboration with a biologist expert in cancer research."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-PoC
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.