Objectif Studies conducted at the Friedrich Meischer Institute (FMI) in Basel have focused on the roles of miRNAs specific to the retina. They have recently shown that absence of functional miRNA expression has severe consequences on mature cone photoreceptors of the mouse retina; a selective and dramatic reduction of cone-specific gene expression arises with the cone-specific loss of regulation by miRNAs in adult mice. The bipolar cells act post-synaptically to the photoreceptors where they not only transmit but also process the light signal received from rods and cones. In this proposal I wish to examine whether absence of functional miRNAs have as severe implications for the bipolar cells as they do for cone photoreceptors. In addition by profiling the miRNA population of these highly specialised neurons I hope to uncover miRNA/mRNA interactions that can fine-tune synaptic transmission and thus contribute to visual processing. Champ scientifique medical and health sciencesclinical medicineophthalmology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2011-IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2011-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Contribution de l’UE € 192 622,20 Adresse MAULBEERSTRASSE 66 4058 Basel Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Type d’activité Research Organisations Contact administratif Dorothy Searles (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Novartis Forschungsstiftung Participation terminée Suisse Contribution de l’UE Aucune donnée Adresse Maulbeerstrasse 66 4058 BASEL Voir sur la carte Type d’activité Research Organisations Contact administratif Dorothy Searles (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
