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Content archived on 2024-06-18

Specificity of Antibiotic Resistance Evolution

Objective

"Bacterial resistance to antibiotics is a major problem for global public health, but we have an incomplete understanding of the evolutionary and genetic factors that drive the spread of resistance. This proposal is motivated by the concept that some of the key processes in resistance evolution depend on the specificity of the genetic mechanisms involved, which is at present unclear. Specificity here refers to variation of the phenotypic effects of mutations across genotypes (epistasis) or environments. I will use a combination of microbial experimental evolution, DNA sequencing and evolutionary genetics to address this problem. My objectives are to: (1) quantify the specificity of antibiotic resistance mutations across different concentrations of a range of antibiotics; (2) identify genetic mechanisms that ameliorate growth defects caused by resistance mutations (compensatory adaptation) in different resistant genotypes in both the presence and absence of antibiotics; (3) test whether compensatory adaptation to the cost of one resistance mutation can also recover the cost of other resistance mutations against the same or other antibiotics. This work will improve our understanding of the genetic and evolutionary factors that drive antibiotic resistance evolution."

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2011-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
EU contribution
€ 184 709,40
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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