Objective
Abstract
Jatrophane are natural compounds isolated from Euphorbia (Euphorbiaceae, spurge family). More than 150 jathrophane have been isolated so far. The general structure is an highly functionalized trans-bicyclo[10.3.0]pentadecane skeleton. Jatrophanes possess a variety of different biological activities such as inhibitory activity on the mammalian mitochondrial respiratory chain, cell cleavage arrest, cytotoxicity against various human cancer cell lines, antiviral activity, antiplasmodial activity, microtubule interaction and cytotoxicity against human cancer cell lines. Most notably, they are inhibitors of the P-glycoprotein (Pgp), a membrane protein whose major function is the active transport of amphiphatic xenotoxins out of the cytoplasm. The over expression of the multi-drug resistance protein 1 (MDR1) gene (which encode for Pgp) contributes to the resistance of cancer cells against a large spectrum of anticancer drugs. Only natural occurring jatrophane have been investigated as modulator of multidrug resistance so far. Despite the large number of jatrophane isolated and the promising biological properties, the preparation this class of compounds can be regarded as a synthetic and biological challenge. The fellow has already an excellent background in synthetic chemistry. This project will allow him to increase his experience and knowledge in natural products chemistry, carbohydrate chemistry, development of bioactive compounds as well as enhance his synthetic experience. He proposes to join NUI Galway which is strategically developing strength in Biomedical Research, Cancer and Glycoscience, thus helping an objective 1 region of Europe to develop its research programme. NUI GAlway will also offer a series of transferrable skills and personal development courses to Dr. Lo Re. Both the scientific and personal training will contribute to the maturing of Dr. Lo Re to becoming an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
H91 Galway
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.