Objectif Microcystins (MC) are potent cyclic heptapeptide toxins that are produced by many cyanobacterial genera e.g. Planktothrix, Microcystis. Human exposure occurs primarily during bloom events, via drinking or contact with contaminated water, food or aerosols. While food exposure and corresponding health effects are rare, exposure to high MC concentrations via drinking water has resulted in morbidity and mortality. However, little is known about the level of MC exposure in humans when sub-chronically or chronically exposed via aerosols or drinking water as is the case in populations living within close proximity to water bodies experiencing toxic blooms, e.g. the population of San Roque dam, Argentina. To accurately determine human exposure, an in-depth understanding of the physical and physiological events governing toxic bloom formation and regulating MC production is critical. In this study we will (1) undertake a series of in-lake mesocosm studies to explore thresholds and triggers of up-regulation of MC. Samples will be analyzed using a suite of sensitive molecular (QPCR, RT-QPCR, metagenome analysis), immunological and chemical techniques in concert with physical and geochemical measurements , (2) undertake a series of field-experiments, incl. the San Roque location, in which we will monitor a range of physiochemical parameters, and in-lake and aerosolized MC levels, and (3) use a hydrodynamic model to define water movement coupled to an ecological model enabling predictions of toxins in aerosols and water. Laboratory techniques and questionnaires specifically developed to allow monitoring of human toxin exposure, will be used to assess health impacts of toxins and aerosols. The consortium represents aquatic ecologists, microbiologist, molecular biologist, modelers, toxicologists and medical staff. Exchanging staff will ensure increased understanding and implementation of technologies and lead to improved human risk assessment. Champ scientifique engineering and technologyenvironmental engineeringwater treatment processesdrinking water treatment processessocial sciencessociologydemographymortality Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2011-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Appel à propositions FP7-PEOPLE-2011-IRSES Voir d’autres projets de cet appel Régime de financement MC-IRSES - International research staff exchange scheme (IRSES) Coordinateur UNIVERSITAT KONSTANZ Contribution de l’UE € 373 800,00 Adresse UNIVERSITATSSTRASSE 10 78464 Konstanz Allemagne Voir sur la carte Région Baden-Württemberg Freiburg Konstanz Type d’activité Higher or Secondary Education Establishments Contact administratif Daniel Dietrich (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire FOLKEHELSEINSTITUTTET Participation terminée Norvège Contribution de l’UE € 168 000,00 Adresse LOVISENBERGGATA 8 0456 Oslo Voir sur la carte Région Norge Oslo og Viken Oslo Type d’activité Research Organisations Contact administratif Hans Utkilen (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée HOGSKOLEN I TELEMARK ORGANISASJONSLEDD Norvège Contribution de l’UE Aucune donnée Adresse KJOLNES RING 56 3918 PORSGRUNN Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Tone Jøran Oredalen (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée