Objective
"The widespread use of magnetic resonance imaging (MRI) technology in clinical and scientific research has attracted great interest in designing high relaxivity contrast agents to improve their sensitivity for the early stage detection of cancer. A number of nanostructure-based T1 contrast agents have been reported in recent years but they are still suffering some limitations for an efficient translation to in vivo applications.
In this proposal, we’ll develop a novel Gd3+-loaded ultrasmall hollow mesoporous silica nanosphere (Gd-UHMSNs) platform as high sensitivity MRI probes for targeting T1-MRI of small animal tumor xenografts and potentially, of cancer patient. The specific aims for the proposal are (1) synthesize UHMSNs, and design routes to couple the particles with Gd-complexes, PEG, RGD or other targeting vectors ; (2) evaluate the relaxivity, toxicity, specific targeting capabilities of Gd-UHMSNs-RGD through tests in cell culture; and (3) evaluate the targeting agents for MRI detection of tumors in different types of mice models. Compared to the current contrast agents, the Gd-UHMSNs-RGD hopefully will show many advantages such as (1) the nanoporous and hollow structural will offer effective geometrical confinement of the Gd-complex and water molecular for enhances the r1 relaxivity, (2) the small particle size < 50 nm, high dispersivity and low toxicity is expected to avoid the RES uptake and efficiently prolong the half-time of circulation in body, (3) the RGD vectors will allow the accumulation of the particles at the tumor endothelium and at the tumor cells.
Success of this project can not only provide theoretical insight to the development of nanoparticle-based high relaxivity and targeting contrast agents, but also guide us to develop a novel contrast agent for pre-scanning patients and personalized nanomedicine, resulting in great commercialization potentials."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology nanomedicine
- medical and health sciences clinical medicine oncology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
10124 TORINO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.