Protein-Repellent Polymers

Projektinformationen

PolyProt

ID Finanzhilfevereinbarung: 299676

Abgeschlossenes Projekt

Startdatum 2 April 2012

Enddatum 1 April 2014

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 193 594,80

EU-Beitrag € 193 594,80

Koordiniert durch

INSTITUT MAX VON LAUE - PAUL LANGEVIN
France

Ziel

"Protein adsorption to material surfaces causes problems in numerous technological and medical applications. A favoured approach in order to prevent protein adsoprtion is to decorate surfaces with brushes of terminally anchored, neutral water soluble polymers (NWSP). But despite the great importance of NWSP-functionalization in medicine and technology, the interaction of proteins with NWSP is not fully understood. In particular, little is known about the mechanisms responsible for regularly observed ""brush failure"", where protein adsorption occurs despite NWSP functionalization. Here, we propose a systematic investigation of this phenomenon on a detailed structural level. Proteins interacting with NWSP-decorated surfaces of defined characteristics (i.e. polymer length and grafting density) will be localized using the combination of two sophisticated scattering techniques:
1) Neutron reflectometry (NR) with contrast variation.
2) Standing-wave x-ray fluorescence (SWXF).
Both techniques possess un-matched spatial resolution and unique, yet complementary, chemical sensitivity. Their combination will reveal the contribution of different interaction modes of proteins with NWSP-decorated surfaces on a quantitative level. The results will provide an invaluable basis for the ""rational design"" of protein-repellent surface functionalization."

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › chemical sciences › polymer sciences

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

INSTITUT MAX VON LAUE - PAUL LANGEVIN

Kontakt Verwaltung

Miriam Forster

• EU-Beitrag: € 193 594,80
• Adresse: 71 AVENUE DES MARTYRS ; 38000 Grenoble ; Frankreich
• Region: Auvergne-Rhône-Alpes › Rhône-Alpes › Isère
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten