Objective
"Protein adsorption to material surfaces causes problems in numerous technological and medical applications. A favoured approach in order to prevent protein adsoprtion is to decorate surfaces with brushes of terminally anchored, neutral water soluble polymers (NWSP). But despite the great importance of NWSP-functionalization in medicine and technology, the interaction of proteins with NWSP is not fully understood. In particular, little is known about the mechanisms responsible for regularly observed ""brush failure"", where protein adsorption occurs despite NWSP functionalization. Here, we propose a systematic investigation of this phenomenon on a detailed structural level. Proteins interacting with NWSP-decorated surfaces of defined characteristics (i.e. polymer length and grafting density) will be localized using the combination of two sophisticated scattering techniques:
1) Neutron reflectometry (NR) with contrast variation.
2) Standing-wave x-ray fluorescence (SWXF).
Both techniques possess un-matched spatial resolution and unique, yet complementary, chemical sensitivity. Their combination will reveal the contribution of different interaction modes of proteins with NWSP-decorated surfaces on a quantitative level. The results will provide an invaluable basis for the ""rational design"" of protein-repellent surface functionalization."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
38000 Grenoble
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.